SCI REP:甲状腺功能与缺血性心脏病!

2017-08-17 xing.T MedSci原创

该研究提供了的证据表明,TSH、FT4和TPOAb阳性并不能明显影响IHD,尽管其对危险因素具有潜在的影响。

近日,Scientific reports 杂志上发表了一篇研究文章,该研究旨在明确甲状腺功能在缺血性心脏病(IHD)中的作用,研究人员根据基因预测的促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)阳性来评估了缺血性心脏病的风险和危险因素。

研究人员将遗传工具(孟德尔随机化)的独立样本的工具变量分析用于广泛的基因型病例(n=64374)和对照(n=130681)研究。研究人员采用全球脂质遗传学协会的结果(n=196475)、遗传复制和病例(n=34380)对照(n=114981)研究的Meta分析以及人体性状的遗传研究(152893名男性和171977名女性的体重指数,93480名男性和116741名女性的腰臀比)来评估脂质、糖尿病和肥胖之间的相关性。

研究人员发现基因预测的甲状腺功能与缺血性心脏病并不存在相关性(TSH每增加一个标准差的比值比(OR)为1.05,95%可信区间(CI)为0.97-1.12;对于FT4为1.01,95%可信区间为0.91-1.12;对于TPOAb阳性为1.10,95%可信区间为0.83-1.46),在对危险因素进行Bonferroni校正后,FT4与低密度脂蛋白胆固醇呈负相关除外。研究人员采用加权平均法进行敏感性分析表明这些相关性一般较强。

该研究提供了的证据表明,TSH、FT4和TPOAb阳性并不能明显影响IHD,尽管其对危险因素具有潜在的影响。

原始出处:

Jie V. Zhao,et al. Thyroid function and ischemic heart disease: a Mendelian randomization study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-07592-z

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    2017-08-21 大爰

    学习并分享!!!

    0

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    2017-08-21 yfjms

    学习了

    0

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    2017-08-19 1e0ece0dm09(暂无匿称)

    谢谢分享

    0

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    2017-08-18 1771ae4158m

    学习一下很不错

    0

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    2017-08-18 184****9840

    学习了谢谢分享

    0

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    2017-08-18 大爰

    学习了谢谢分享!!

    0

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    2017-08-18 lou.minghong

    很有用的资讯,学习了谢谢分享!

    0

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