Gastroenterology :炎症性肠病中的性别差异

2018-06-28 zhangfan MedSci原创

研究发现,不同年龄段人群的炎症性肠病风险存在性别差异,这一现象可能是性激素差异导致的表观遗传、遗传以及生活方式因素的综合作用结果

炎症性肠病(IBD)的发病率随年龄变化显著,但很少有研究考察性别对IBD发病的影响。近日研究人员就不同年龄段IBD发病率的性别差异进行了考察。

研究考察了欧洲、北美、澳大利亚和新西兰的16个地区IBD患者资料,总计95605例克罗恩病病例(CD,男性42831例,女性52774例)以及112004例溃疡性结肠炎病例(UC,男性61672名,女性52774名)。研究人员计算CD和UC的发病率,并采用随机效应荟萃分析模型考察了性别差异。

研究发现女性人群儿童期CD发病率较低,在10-14岁阶段期CD发病率比值比为0.70,但随后女性CD发病率增加,25-29岁及35岁以上女性人群的CD发病率变化显著。45岁以前,男女人群UC发病率差异不显著(5-9岁除外),但男性45岁之后的UC风险显著高于女性。

研究发现,不同年龄段人群的炎症性肠病风险存在性别差异,这一现象可能是性激素差异导致的表观遗传、遗传以及生活方式因素的综合作用结果。

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    2019-05-24 许安
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