ESPID 2020:小儿肝移植术后,多药耐药革兰氏阴性菌感染高发

2020-11-01 MedSci原创 MedSci原创

“该发现强调了移植前对多药耐药病原体进行筛查和严格监控的重要性。”

在欧洲儿童传染病学会(ESPID)第38届年会上,一项针对接受肝移植儿童的回顾性研究发现:小儿肝移植术后多药耐药革兰氏阴性菌感染率相对较高。

在这项研究中,研究人员回顾性研究了2010年1月至2018年12月期间118名肝移植儿童患者的数据。结果显示,在术后3个月内,有119例(54.2%)患者发生细菌感染。其中58例(48.7%)是由于多重耐药的革兰氏阴性菌感染,肺炎克雷伯菌(32.7%)和大肠杆菌(31%)则是最常见的多药耐药革兰氏阴性菌。

患者的总死亡率达6.7%。感染的中位时间为术后9天,最常见的感染部位是腹腔(46.4%)。

Significant Advance Reported in the Battle against Multidrug-Resistant  Bacteria

图片来源:https://www.genengnews.com/topics/translational-medicine/significant-advance-reported-in-the-battle-against-multidrug-resistant-bacteria/

研究人员Sophida Boonsathorn指出:“该发现强调了移植前对多药耐药病原体进行筛查和严格监控的重要性。”

研究人员还评估了哪些临床特征可能预示着多重耐药性革兰氏阴性菌感染。单因素分析的结果显示了几个潜在的重要因素,包括肝移植前使用抗生素,小儿终末期肝病评分>21和胆汁渗漏。

细菌产生抗生素抗性的机制(图片来源:http://modmedmicro.nsms.ox.ac.uk/learn-more-about-antibiotic-resistance/)

原始出处:

https://www.firstwordpharma.com/node/1769826?tsid=1

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    2021-07-10 whmdzju
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    2021-01-24 cy0324
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    2020-11-02 1478bfb4m38(暂无昵称)

    好好学习,天天向上!

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