Diabetes Care:传统心血管危险因素可进一步降低糖尿病患者死亡率

2015-03-11 小田 译 医学论坛网

美国一项研究表明,更多关注糖尿病成人患者的传统心血管危险因素(血糖、血压、血脂和吸烟)确实可进一步降低其心血管事件和死亡率。相关文章2月20日在线发表于《糖尿病护理》(Diabetes Care)杂志。 研究者旨在评估糖化血红蛋白(A1c)控制不佳、高低密度脂蛋白胆固醇(LDL-C)、高血压和当前吸烟的糖尿病成人患者的严重心血管疾病住院事件和全因死亡。纳入859617例成人糖尿病

美国一项研究表明,更多关注糖尿病成人患者的传统心血管危险因素(血糖、血压、血脂和吸烟)确实可进一步降低其心血管事件和死亡率。相关文章2月20日在线发表于《糖尿病护理》(Diabetes Care)杂志。

研究者旨在评估糖化血红蛋白(A1c)控制不佳、高低密度脂蛋白胆固醇(LDL-C)、高血压和当前吸烟的糖尿病成人患者的严重心血管疾病住院事件和全因死亡。纳入859617例成人糖尿病患者。将以下这些危险因素控制不佳进行分类:LDL-C ≥100 mg/dL,A1C ≥7% (53 mmol/mol),BP ≥140/90 mm Hg或吸烟。根据基层医院出院诊断为心肌梗死(MI)和急性冠脉综合征(ACS)、卒中或心力衰竭(HF)定义为严重心血管事件。利用泊松回归模型评估5年事件发生率、比值比(OR)和平均归因比例。

结果显示,受试者基线平均年龄为59岁,女性48%,白人45%,有心血管疾病比例为31%。平均随访59个月。伴和不伴心血管疾病的糖尿病患者的事件发生率/100人-年,MI/ACS为6.0 对1.7,卒中为5.3对1.5,HF 为8.4对1.2,全因死亡率为18.1对5.0。

在伴心血管疾病的糖尿病患者中,与危险因素控制不佳相关的心血管事件和死亡百分比分别为11% 和3%;在不伴心血管疾病的糖尿病患者中,上述百分比分别为34%和7%。

原始出处:

Vazquez-Benitez G1, Desai JR2, Xu S3, Goodrich GK3, Schroeder EB3, Nichols GA4, Segal J5, Butler MG6, Karter AJ7, Steiner JF3, Newton KM8, Morales LS9, Pathak RD10, Thomas A11, Reynolds K12, Kirchner HL13, Waitzfelder B14, Elston Lafata J15, Adibhatla R2, Xu Z2, O'Connor PJ2.Preventable Major Cardiovascular Events Associated With Uncontrolled Glucose, Blood Pressure, and Lipids and Active Smoking in Adults With Diabetes With and Without Cardiovascular Disease: A Contemporary Analysis.Diabetes Care. 2015 Feb 20. pii: dc141877. [Epub ahead of print]

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  5. 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href='/topic/show?id=28c351e80dc' target=_blank style='color:#2F92EE;'>#心血管危险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51780, encryptionId=28c351e80dc, topicName=心血管危险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3e0221357465, createdName=lingaifan, createdTime=Fri Mar 13 00:18:00 CST 2015, time=2015-03-13, status=1, ipAttribution=)]
    2015-06-11 ljjj1053

    好好学习一下

    0

  6. 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    2015-04-11 x35042875

    AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性

    0

  8. 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