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CLIN CANCER RES：CSF1R基因改变通过改变巨噬细胞功能调节肿瘤免疫

2017-10-27 MedSci MedSci原创

巨噬细胞肿瘤免疫CSF1R
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通过抑制集落刺激因子1（CSF-1R）靶向肿瘤相关巨噬细胞是肿瘤治疗的策略之一。CLIN CANCER RES近期发表了一篇文章，研究CSF1R基因改变对CSF-1R信号以及CSF-1R抑制剂敏感性的影响。

通过抑制集落刺激因子1（CSF-1R）靶向肿瘤相关巨噬细胞是肿瘤治疗的策略之一。CLIN CANCER RES近期发表了一篇文章，研究CSF1R基因改变对CSF-1R信号以及CSF-1R抑制剂敏感性的影响。

作者研究了140例肿瘤患者中CSF1R基因改变情况。检测CSF-1R磷酸化，细胞内吞作用以及巨噬细胞极化以了解对CSF-1刺激的反应。利用肿瘤组织标本中的肿瘤相关巨噬细胞以及对CSF-1R抑制剂敏感性研究巨噬细胞功能。研究结果发现CSF1R c.1085＞G基因改变是在在东亚人群中出现的高频率等位基因。存在这种等位基因变化的肿瘤患者M2样肿瘤相关巨噬细胞更少，且伴随肿瘤组织中VEGF低表达。重要的是，CSF1R基因改变与结直肠癌、子宫内膜癌以及卵巢癌无病生存显着相关。存在CSF1R c.1085＞G基因改变的巨噬细胞对CSF-1刺激具有抵抗性。IC50在0.1nmol/L到1nmol/L时，巨噬细胞对CSF-1R抑制剂敏感。CSF-1诱导磷酸化以及CSF-1R快速内吞作用，导致CSF1Rc.1085基因型A_A巨噬细胞M2样磷酸化，其中IC50在10nmol/L到100nmol/L时，PLX3997，BLZ945和GW2580抑制剂抑制巨噬细胞生存。

文章最后认为，CSF1R c.1085＞G基因改变通过改变巨噬细胞磷酸化和功能调节肿瘤免疫作用，可以作为靶向CSF-1R信号进行肿瘤治疗的分子标志。

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    2017-11-05 12498adam51暂无昵称

    #基因改变#

    0

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    2018-09-26 kcb078

    #CSF#

    0

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    2017-12-17 839640778

    #CSF1#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1740045, encodeId=3a2b1e400450c, content=<a href='/topic/show?id=1dc741e55ed' target=_blank style='color:#2F92EE;'>#基因改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41755, encryptionId=1dc741e55ed, topicName=基因改变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6eda34632749, createdName=12498adam51暂无昵称, createdTime=Sun Nov 05 03:59:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668847, encodeId=06dd166884e72, content=<a href='/topic/show?id=a41d5339c1' target=_blank style='color:#2F92EE;'>#CSF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5339, encryptionId=a41d5339c1, topicName=CSF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5226466702, createdName=kcb078, createdTime=Wed Sep 26 18:59:00 CST 2018, time=2018-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783853, encodeId=b23f1e8385367, content=<a href='/topic/show?id=ddc15341d3' target=_blank style='color:#2F92EE;'>#CSF1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5341, encryptionId=ddc15341d3, topicName=CSF1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Dec 17 02:59:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082058, encodeId=ea33208205870, content=<a href='/topic/show?id=73c95342e9' target=_blank style='color:#2F92EE;'>#CSF1R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5342, encryptionId=73c95342e9, topicName=CSF1R)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Thu May 17 14:59:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262001, encodeId=b1ef26200107, content=学习学习了.谢谢啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Fri Nov 17 10:52:54 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259563, encodeId=18ef259563ac, content=非常好.幸亏个子低, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Nov 07 23:43:27 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586806, encodeId=7f5015868069d, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sun Oct 29 00:59:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256633, encodeId=98ee25663387, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 28 10:15:44 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256375, encodeId=a2ee2563e588, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Fri Oct 27 12:39:09 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2018-05-17 ms7899726347904398

    #CSF1R#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1740045, encodeId=3a2b1e400450c, content=<a href='/topic/show?id=1dc741e55ed' target=_blank style='color:#2F92EE;'>#基因改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41755, encryptionId=1dc741e55ed, topicName=基因改变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6eda34632749, createdName=12498adam51暂无昵称, createdTime=Sun Nov 05 03:59:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668847, encodeId=06dd166884e72, content=<a href='/topic/show?id=a41d5339c1' target=_blank style='color:#2F92EE;'>#CSF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5339, encryptionId=a41d5339c1, topicName=CSF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5226466702, createdName=kcb078, createdTime=Wed Sep 26 18:59:00 CST 2018, time=2018-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783853, encodeId=b23f1e8385367, content=<a href='/topic/show?id=ddc15341d3' target=_blank style='color:#2F92EE;'>#CSF1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5341, encryptionId=ddc15341d3, topicName=CSF1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Dec 17 02:59:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082058, encodeId=ea33208205870, content=<a href='/topic/show?id=73c95342e9' target=_blank style='color:#2F92EE;'>#CSF1R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5342, encryptionId=73c95342e9, topicName=CSF1R)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Thu May 17 14:59:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262001, encodeId=b1ef26200107, content=学习学习了.谢谢啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Fri Nov 17 10:52:54 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259563, encodeId=18ef259563ac, content=非常好.幸亏个子低, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Nov 07 23:43:27 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586806, encodeId=7f5015868069d, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sun Oct 29 00:59:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256633, encodeId=98ee25663387, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 28 10:15:44 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256375, encodeId=a2ee2563e588, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Fri Oct 27 12:39:09 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-11-17 微分

    学习学习了.谢谢啦

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1740045, encodeId=3a2b1e400450c, content=<a href='/topic/show?id=1dc741e55ed' target=_blank style='color:#2F92EE;'>#基因改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41755, encryptionId=1dc741e55ed, topicName=基因改变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6eda34632749, createdName=12498adam51暂无昵称, createdTime=Sun Nov 05 03:59:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668847, encodeId=06dd166884e72, content=<a href='/topic/show?id=a41d5339c1' target=_blank style='color:#2F92EE;'>#CSF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5339, encryptionId=a41d5339c1, topicName=CSF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5226466702, createdName=kcb078, createdTime=Wed Sep 26 18:59:00 CST 2018, time=2018-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783853, encodeId=b23f1e8385367, content=<a href='/topic/show?id=ddc15341d3' target=_blank style='color:#2F92EE;'>#CSF1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5341, encryptionId=ddc15341d3, topicName=CSF1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Dec 17 02:59:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082058, encodeId=ea33208205870, content=<a href='/topic/show?id=73c95342e9' target=_blank style='color:#2F92EE;'>#CSF1R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5342, encryptionId=73c95342e9, topicName=CSF1R)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Thu May 17 14:59:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262001, encodeId=b1ef26200107, content=学习学习了.谢谢啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Fri Nov 17 10:52:54 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259563, encodeId=18ef259563ac, content=非常好.幸亏个子低, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Nov 07 23:43:27 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586806, encodeId=7f5015868069d, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sun Oct 29 00:59:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256633, encodeId=98ee25663387, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 28 10:15:44 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256375, encodeId=a2ee2563e588, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Fri Oct 27 12:39:09 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-11-07 微分

    非常好.幸亏个子低

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1740045, encodeId=3a2b1e400450c, content=<a href='/topic/show?id=1dc741e55ed' target=_blank style='color:#2F92EE;'>#基因改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41755, encryptionId=1dc741e55ed, topicName=基因改变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6eda34632749, createdName=12498adam51暂无昵称, createdTime=Sun Nov 05 03:59:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668847, encodeId=06dd166884e72, content=<a href='/topic/show?id=a41d5339c1' target=_blank style='color:#2F92EE;'>#CSF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5339, encryptionId=a41d5339c1, topicName=CSF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5226466702, createdName=kcb078, createdTime=Wed Sep 26 18:59:00 CST 2018, time=2018-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783853, encodeId=b23f1e8385367, content=<a href='/topic/show?id=ddc15341d3' target=_blank style='color:#2F92EE;'>#CSF1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5341, encryptionId=ddc15341d3, topicName=CSF1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Dec 17 02:59:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082058, encodeId=ea33208205870, content=<a href='/topic/show?id=73c95342e9' target=_blank style='color:#2F92EE;'>#CSF1R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5342, encryptionId=73c95342e9, topicName=CSF1R)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Thu May 17 14:59:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262001, encodeId=b1ef26200107, content=学习学习了.谢谢啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Fri Nov 17 10:52:54 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259563, encodeId=18ef259563ac, content=非常好.幸亏个子低, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Nov 07 23:43:27 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586806, encodeId=7f5015868069d, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sun Oct 29 00:59:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256633, encodeId=98ee25663387, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 28 10:15:44 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256375, encodeId=a2ee2563e588, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Fri Oct 27 12:39:09 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-10-29 般若傻瓜

    #细胞功能#

    0

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    2017-10-28 flysky120

    学习一下知识了

    0

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    2017-10-27 明天会更好！

    不错的文章值得推荐一下

    0

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