JACC Cardiovasc Inte:OCT定义的易损斑块与功能性狭窄程度及微血管障碍相关

2018-11-11 国际循环编辑部 国际循环

众所周知,心外膜病变及微血管功能障碍的严重程度均与不良临床结局具有相关性。JACC:Cardiovascular Interventions发表的一项最新研究探讨不稳定斑块特征与生理病变严重程度及微血管功能障碍的相关性。

众所周知,心外膜病变及微血管功能障碍的严重程度均与不良临床结局具有相关性。JACC:Cardiovascular Interventions发表的一项最新研究探讨不稳定斑块特征与生理病变严重程度及微血管功能障碍的相关性。

研究共计对340例行光学相干断层扫描(OCT)、血流储备分数(FFR)检查及微循环阻力指数(IMR)评估的患者共计382处原发中重度冠状动脉病变进行分析。根据FFR、IMR数值对病变进行三分位距分组[FFR-T1(FFR<0.74),FFR-T2(0.74≤FFR≤0.81)和IMR-T1(IMR≥25),IMR-T2(15

结果发现,FFR与IMR并无明显相关性。与IMR-T2及IMR-T3组相比,IMR-T1组OCT定义的薄纤维帽粥样斑块(TCFA)患病率明显更高。总之,不同FFR三分位距组TCFAs患病率存在明显差异,但成对比较未发现显著统计学意义。尽管与IMR-T2及IMR-T3组相比,IMR-T1组的斑块破裂发生率明显更高,但FFR各三分位距组之间并无明显差异。多因素分析显示,FFR及IMR均是TCFAs患病率的独立预测因素,OR值分别为0.036(95%CI:0.004~0.342,P=0.004)和1.034(95%CI:1.014~1.054,P=0.001)。

上述结果提示,FFR较低及IMR较高是血管造影显示存在中重度稳定病变或非罪犯病变的急性冠状动脉综合征患者存在TCFA的独立预测因素。

原始出处:
Eisuke Usui, Taishi Yonetsu, Yoshihisa Kanaji, et al. Optical Coherence Tomography–Defined Plaque Vulnerability in Relation to Functional Stenosis Severity and Microvascular Dysfunction. JACC: Cardiovascular Interventions. Oct 2018.

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    2019-08-04 quxin068
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    2019-07-01 hbwxf
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    2019-08-09 habb
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1938885, encodeId=75811938885ea, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Aug 04 04:31:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854224, encodeId=dc291854224bb, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jul 01 18:31:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858337, encodeId=5541185833e7d, content=<a href='/topic/show?id=21311323521' target=_blank style='color:#2F92EE;'>#OCT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13235, encryptionId=21311323521, topicName=OCT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Fri Aug 09 13:31:00 CST 2019, time=2019-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915493, encodeId=2aa9191549371, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Apr 25 12:31:00 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326033, encodeId=03c8132603346, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Nov 13 06:31:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330104, encodeId=30bb1330104f7, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Nov 13 06:31:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365355, encodeId=32a91365355f3, content=<a href='/topic/show?id=2a2150e76fd' target=_blank style='color:#2F92EE;'>#微血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50776, encryptionId=2a2150e76fd, topicName=微血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Tue Nov 13 06:31:00 CST 2018, time=2018-11-13, status=1, ipAttribution=)]
    2018-11-13 mgqwxj