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Diabetologia：FAM13A和POM121C是空腹胰岛素的候选基因

2018-07-03 MedSci MedSci原创

候选基因空腹胰岛素
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近日，国际杂志 《Diabetologia》上在线发表一项关于全基因组关联研究的功能性后续分析的研究，FAM13A和POM121C是空腹胰岛素的候选基因。 研究人员通过全基因组关联荟萃分析，已经确定了17个与空腹血清胰岛素（FSI）相关的基因位点，这是全身性胰岛素抵抗的标志。为了在这些基因座中定义潜在的“犯罪”基因，在横断面研究中，研究人员分析了这些基因座中120个与全身和脂肪组织变量相关的

近日，国际杂志 《Diabetologia》上在线发表一项关于全基因组关联研究的功能性后续分析的研究，FAM13A和POM121C是空腹胰岛素的候选基因。 研究人员通过全基因组关联荟萃分析，已经确定了17个与空腹血清胰岛素（FSI）相关的基因位点，这是全身性胰岛素抵抗的标志。为了在这些基因座中定义潜在的“犯罪”基因，在横断面研究中，研究人员分析了这些基因座中120个与全身和脂肪组织变量相关的基因的白色脂肪组织（WAT）表达，并功能性评估了在WAT（eQTLs）中显示基因型特异性表达的基因。研究人员对114名妇女腹部皮下脂肪组织活检。以从脂肪组织外植体释放的甘油测量基础脂肪分解活性。通过分离脂肪细胞并使用胰岛素刺激的放射性标记的葡萄糖掺入脂质来测定脂肪细胞胰岛素敏感性。利用人类间充质干细胞中的小干扰RNA介导的敲除来评估基因功能。 研究发现，所研究的候选基因中48个的脂肪表达与FSI显著相关，而，分别有24,17和2基因的表达与脂肪细胞胰岛素敏感性、脂解和/或WAT形态学相关（即相对于总体脂肪量的脂肪细胞大小）。四个基因座位包含eQTL。在一个4号染色体基因座（rs3822072），FS

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    2018-08-07 baoya

    #胰岛#

    0

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    2019-05-30 12498a1cm78暂无昵称

    #候选基因#

    0

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    2019-05-12 ms9608593228839890

    #DIA#

    0

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    2019-03-12 ms5439512287675881

    #BET#

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