JAMA:颠覆!肥胖不再与高死亡率有关?

2016-05-15 sunshine&KL MedSci原创

JAMA:颠覆!肥胖不再与高死亡率有关?肥胖会比40年前更危险吗?来自丹麦哥本哈根大学的一项新的研究表明,自20世纪70年代发现肥胖可增加30%过早死亡的风险以来到现在肥胖对死亡的风险已经降至零,该研究发现已在线发表于JAMA。研究人员分析了超10万人的数据,1976-1978年(n = 13704)的研究数据显示肥胖者全因过早死亡的风险较比正常体重者高,但是2003-2013年(n = 9736

导语:我们需要重新定义超重标准吗?

肥胖的危险性会比40年前降低吗?来自丹麦哥本哈根大学的一项新的研究表明,自20世纪70年代发现肥胖可增加30%过早死亡的风险以来,目前的研究表明肥胖对死亡的风险已降至零,该研究于5月10日在线发表于JAMA。

研究人员分析了超10万人的数据,1976-1978年(n = 13704),研究数据显示肥胖者全因过早死亡的风险较正常体重者高,但是2003-2013年(n = 97362)的研究数据却并未有此发现。

首席研究员Shoaib Afzal博士,来自哥本哈根大学医院Herlev医院,说道:“与正常体重相比,肥胖增加的全因死亡率由1976-78年的30%下降至2003-2013年的0%。”

在许多国家,公共卫生政策均建议人们保持一个健康的体重,以避免慢性疾病的发生,如糖尿病和心血管疾病,从而避免过早死亡。

对于成年人来说,BMI的范围:

≥30则为肥胖;

25-29.9则为超重;

18.5-24.9则为正常或健康的体重;

<18.5则为体重过轻。

研究还发现,1976-78年、1991-1994年以及2003-2013年与全因最低死亡率有关的BMI的范围各不同。随访所有的参与者至2014。

没有理由变成超重状态

Afzal博士写道,他们发现与最低死亡风险相关的BMI从1976-1978年的23.7上升到1991-1994年的24.6,然后再次上升至2003-2013年的27。

但是,体重指数低于或高于这些值的个体的死亡风险更高。

超重的标准需要重新定义吗?各家观点

肯定观点:

资深作者BøRGE G. Nordestgaard,哥本哈根大学和哥本哈根大学医院的临床教授,表示导致这种变化的原因尚未清楚,但他认为该研究结果表明超重需要重新定义。

他还补充道:“重要的是,我们的研究结果不应被解释为,现在人们想吃多少就吃多少,或是所谓的正常体重的人应该吃更多变得超重。尽管如此,但是超重的人也许不必像以前那样担心自己的体重。”

否定观点:

对这项研究的评论中,来自英国格拉斯哥大学的代谢医学教授Naveed Sattar说道,尽管结果十分有趣,但是仍不能改变对于肥胖的建议以及肥胖的治疗和预防措施。

他解释道,现代药物可以帮助存在某些危险因素(如肥胖)的人们活的更久,但是他认为并不能基于本项研究就可以说需要重新定义肥胖。

例如,人们可获得更多的廉价的、预防性的药物,这意味着许多超重和肥胖的人正在接受2型糖尿病、高血压及高胆固醇的治疗,而这些药物的方便获取也降低了患者的死亡风险。

“肥胖和超重还是许多疾病的危险信号,如2型糖尿病,肝脏疾病,癌症,睡眠问题,多胎妊娠并发症等,虽然目前这其中的许多疾病我们可以很好地管理,但是这些并发症肯定会影响我们的生活质量,伤害自尊,并且增加社会的医疗成本。”

PS:

在此研究中,与最低死亡风险相关的BMI从1976-1978年的23.7上升到1991-1994年的24.6,然后再次上升至2003-2013年的27。且体重指数低于或高于这些值的个体的死亡风险更高。这表明,控制合理且稳定的BMI对人们的生活和健康依旧是十分重要的,近期发表在BMJ杂志的研究发现,一生中稳定保持瘦体型的人死亡率最低。研究人员同时指出,从5到50岁,较重体型尤其是中年体重增加与死亡率增加相关。

所以,您如何看待肥胖对生活的影响,以及超重标准的变化呢?欢迎发表您的观点:

肥胖对生活影响太大,没什么好辩解的

随着医疗水平的改进,可提高超重标准

保持稳定的合理的BMI就可以了,太胖,太瘦都不行

路过的胖子(BMI>25)

路过的瘦子(BMI<18.5)

原始出处:

Shoaib Afzal et al., Change in body mass index associated with lowest mortality in Denmark, 1976-2013, JAMA, doi:10.1001/jama.2016.4666, published online 10 May 2016.

Catharine Paddock. Obesity no longer linked to higher risk of death. MNT,15 May 2016.

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    2016-10-06 1e10c84am36(暂无匿称)

    文章真心很好,感谢作者

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    2016-08-29 ylzr123

    深入学习,好文值得点赞!

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    2016-07-21 The one 00000

    话是这样,但很多慢性疾病是与肥胖成正比的

    0

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    2016-07-10 oo902

    好文章,学习了

    0

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    2016-05-16 永圣

    肥胖应该控制,浪费的太多了!

    0

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    2016-05-15 lovetcm

    仅仅BMI受质疑,应该区分内脏脂肪多少,或白色脂肪含量

    0

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    2016-05-15 西海五月

    22.75,还是重一点儿!

    0

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    2016-05-15 西海五月

    22.75,还是重一点儿!

    0

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    2016-05-15 xiaotaiyang1

    20~22之间徘徊

    0

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