轻症患者没必要住院?新英格兰医学杂志报告德国病例:警惕无症状者也可携带新冠病毒

2020-02-03 卢芳 文韬 中国循环杂志

《新英格兰医学杂志》报告了一个德国新型冠状病毒(2019-nCoV)感染病例。1月21~22日,德国慕尼黑有一场商务会议,会上就有一位来自中国上海的同事。她当时在德时身体状况良好,没有不舒服,但在返回航班上开始发病,26日检测2019-nCoV阳性。这位患者即图1中的源头患者。会上有位身体健康的33岁德国男士。1月24日,他因喉咙痛、发冷和肌痛就诊,次日发热39.1℃,伴咳嗽。不过情况渐好,27日

《新英格兰医学杂志》报告了一个德国新型冠状病毒(2019-nCoV)感染病例。

1月21~22日,德国慕尼黑有一场商务会议,会上就有一位来自中国上海的同事。

她当时在德时身体状况良好,没有不舒服,但在返回航班上开始发病,26日检测2019-nCoV阳性。这位患者即图1中的源头患者。

会上有位身体健康的33岁德国男士。

1月24日,他因喉咙痛、发冷和肌痛就诊,次日发热39.1℃,伴咳嗽。

不过情况渐好,27日,男子回来上班。



图1 暴露于无症状2019-nCoV感染者后,数位患者病情监测时间线

源头患者于27日向公司汇报。所有接触者被追踪,这位德国男士被送往医院观察。

该男子无发热,且身体状况良好,发病前2周没有离开德国,但两份鼻咽拭子和一份痰液样本检测结果显示2019-nCoV阳性。

而且直到1月29日,痰液样本中病毒载量依然很高,达到108copies/ml。

该公司还有3人被检出2019-nCoV阳性,但只1位与来自上海的同事有接触,其他2人均与33岁德国男士有接触。

目前4人均隔离中,没有发现有严重的症状。

作者认为,2019-nCoV感染者,也可能没有症状,这需要重新评估病毒的传播。

而且,还需要警惕,恢复期患者的痰液中也可检测到2019-nCoV的病毒量。但检测到的病毒活力仍有待于查证。

但作者指出,这四名患者症状轻微,住院并非需要治疗,而是因公众安全。由于医院的医疗资源有限,特别是适值流感高峰季,因此需要进行研究,以确定是否可以不住院,而在院外接受适当的指导来治疗。

来源:Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. N Engl J Med. 2020 Jan 30.

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    2020-02-03 公卫新人

    新冠肺炎,疫情何时才能消失

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