Sci Rep:较低的SHBG水平与较高的瘦蛋白、较低的脂肪连接蛋白水平和代谢综合征有关,而与睾丸素无关

2017-06-04 AlexYang MedSci原创

除了睾丸素外(T),性激素结合球蛋白(SHBG)在代谢综合征(MetS)中的角色越来越受到关注并给予了注释。然而,关于血清脂肪细胞因子水平的相关关系研究仍旧十分有限。因此,最近,有研究人员评估了是否血清睾丸素和性激素结合球蛋白是代谢综合征的独立的预测因子。另外,该代谢综合征与脂肪连接蛋白和瘦蛋白相关,且群体为来自一个自由健康筛选的614名台湾地区的年龄不小于40岁的男性。研究发现,最低四分位的睾丸

除了睾丸素外(T),性激素结合球蛋白(SHBG)在代谢综合征(MetS)中的角色越来越受到关注并给予了注释。然而,关于血清脂肪细胞因子水平的相关关系研究仍旧十分有限。因此,最近,有研究人员评估了是否血清睾丸素和性激素结合球蛋白是代谢综合征的独立的预测因子。另外,该代谢综合征与脂肪连接蛋白和瘦蛋白相关,且群体为来自一个自由健康筛选的614名台湾地区的年龄不小于40岁的男性。

研究发现,最低四分位的睾丸素和性激素结合球蛋白水平的患者发展为代谢综合征是那些最高四分位睾丸素和性激素结合球蛋白水平的患者的1.58倍和3.22倍。然而,性别结合球蛋白保留了其作为代谢综合征的独立风险预测因子,而与睾丸素无关,但是反之不然。另外,在调整了睾丸素水平后,性激素结合球蛋白与脂肪连接蛋白和瘦蛋白显著相关。最后,研究人员指出,SHBG是MetS的主要预测风险因子,并且与血清脂肪连接蛋白和瘦蛋白相关,且与睾丸素无关。进一步的研究是需要的,从而阐释SHBG在MetS病理中的真实角色和与血清脂肪连接蛋白和瘦蛋白水平相关的机制。

原始出处:


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    2017-06-06 zhangph
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    2017-06-06 zhty5343

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