Antimicrob Agents Ch:哪些因素会影响社区成人菌血症患者的不良结局?

2017-12-28 梁舒瑶 环球医学

2017年发表在《Antimicrob Agents Chemother》上的一项回顾性队列研究,对社区发生的成人菌血症的年龄相关趋势进行了考察。

2017年发表在《Antimicrob Agents Chemother》上的一项回顾性队列研究,对社区发生的成人菌血症的年龄相关趋势进行了考察。

为了解不同年龄人群中菌血症特征的流行病学变量,在一个回顾性队列中研究6年期内社区发生的成人菌血症。

2349名菌血症患者被分为4个年龄类型:青年(18-44岁;196名患者;8.3%)、成人(45-64岁;707名患者;30.1%)、老年人(65-84岁;1098名患者;46.7%)和高龄老人(≥85岁;384名患者;14.8%)。对菌血症发病疾病危重程度的年龄相关趋势(皮特菌血症得分≥4)、抗生素耐药的病原体(广谱β-内酰胺酶[ESBL]产生的大肠杆菌,克雷伯菌和奇异变形杆菌[EKP];耐甲氧西林金黄色葡萄球菌[MRSA];左氧沙星不敏感EKP)、不恰当的经验性抗生素疗法(EAT)和4周死亡率进行观察。采用多变量回归模型,菌血症发生时重大疾病(校正比值比[AOR],9.03;P<0.001)和不恰当的EAT(AOR,2.67;P<0.001)是4周死亡率的两大主要预测因素。此外,ESBL产生的EKP(AOR,12.94;P<0.001)、MRSA(AOR,8.66;P<0.001)以及左氧沙星不敏感EKP(AOR,4.27;P<0.001)与不恰当的EAT相关。总体上,在社区发生的成人菌血症中,抗生素耐药病原体和菌血症严重程度可见显着的年龄正相关趋势,并且与不恰当的EAT发生率和4周死亡率的增加相关。因此,不同年龄组应该考虑不同的经验性抗菌方案。

原始出处:
Lee CC, Wang JL, Lee CH, et al.Age-Related Trends in Adults with Community-Onset Bacteremia.Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01050-17. doi: 10.1128/AAC.01050-17. Print 2017 Dec.

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    2018-09-28 xjy02
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    2018-10-04 wjywjy
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    2018-01-02 grace5700
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    2018-01-02 stupidox

    学习了.谢谢分享

    0

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    2017-12-29 半夏微凉

    学习了谢谢分享

    0

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    2017-12-29 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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