Hypertension:原发性蛋白尿性肾小球病患者的血压和血压变异性!

2017-07-03 xing.T MedSci原创

由此可见,在入选NEPTUNE的成人和儿童中高血压状态很是常见。根据年龄和组织学诊断,研究人员发现高血压状态患病率、BPV和治疗存在差异。此外,高血压状态和更大的BPV与较差的临床结局相关。

原发性蛋白尿性肾小球病患者中高血压和血压变异性(BPV; SD和平均实际变异)还没有很好地被描述。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,所用数据来自NEPTUNE研究(肾病综合征研究网络)的433名参与者。高血压血压状态定义是:以前有高血压病史、成人血压≥140/90mmHg或儿童基线血压水平≥第95百分位数。研究人员测量了第一年内进行了3次访视的参与者的BPV。

研究人员共评估了二百九十六名成年人(43岁[四分位距为32-57.8岁],男性占61.5%)和147名儿童(11岁[四分位距为5-14岁],男性占57.8%)。在基线时,64.8%的成年人和46.9%的儿童被诊断为高血压。组织学诊断与成人高血压状态有关(P=0.036)。

在成人中,高血压状态与较低的完全缓解风险相关(风险比为0.36; 95%CI为0.19-0.68),并且达到复合终点的风险更大(肾脏疾病终末期或估计的肾小球滤过率下降>40%;风险比为4.1; 95%CI为1.4-12)。更大的收缩期和舒张期SD和平均实际变异也与成人达到复合终点的更大风险相关(均P<0.01)。在儿童中,更大的BPV是复合终点(由收缩期SD和平均实际变异来确定)的独立预测因子和完全缓解(由收缩期和舒张期平均实际变异来确定;所有P<0.05)。

由此可见,在入选NEPTUNE的成人和儿童中高血压状态很是常见。根据年龄和组织学诊断,研究人员发现高血压状态患病率、BPV和治疗存在差异。此外,高血压状态和更大的BPV与较差的临床结局相关。

原始出处:


Christine B. Sethna,et al. Blood Pressure and Visit-to-Visit Blood Pressure Variability Among Individuals With Primary Proteinuric Glomerulopathies.Hypertension.2017. https://doi.org/10.1161/HYPERTENSIONAHA.117.09475

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 04 06:10:05 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 04 06:10:05 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
  6. 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likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Tue Jul 04 22:48:59 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218596, encodeId=c8a52185966c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Jul 04 22:32:28 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218369, encodeId=72572183695c, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 04 06:10:05 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 131****2916

    不错的文章值得学习

    0

  7. 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likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Tue Jul 04 22:48:59 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218596, encodeId=c8a52185966c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Jul 04 22:32:28 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218369, encodeId=72572183695c, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 04 06:10:05 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  8. 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likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Tue Jul 04 22:48:59 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218596, encodeId=c8a52185966c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Jul 04 22:32:28 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218369, encodeId=72572183695c, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 04 06:10:05 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 龙胆草

    学习谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2038711, encodeId=9dd32038e1151, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Thu Jul 13 04:21:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1846562, encodeId=5514184656289, content=<a href='/topic/show?id=d3a33e0306d' target=_blank style='color:#2F92EE;'>#原发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37030, encryptionId=d3a33e0306d, topicName=原发性)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 04 06:10:05 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 txqjm

    谢谢了,学习

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 04 06:10:05 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 天地飞扬

    学习了,谢谢分享

    0