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JCO：立体定向放射治疗加化疗可提高IV期肺癌患者的生存率

2015-01-04 zhangjialiang译 MedSci原创

立体定向放疗肺癌
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UT西南医学中心的癌症研究人员报道，在一个结合立体定向放射治疗与特定的化疗方案临床试验中，IV期肺癌患者的生存率增加了一倍多。相比单用厄洛替尼治疗的仅仅6 - 9个月的生存时间，名为SBRT的体部立体定向放射治疗与化疗药厄洛替尼的结合，能够提高总生存时间至20个月。这种联合治疗能够延长患者无进展生存期，使相似的肺癌患者无进展生存期从以前的2-4个月延长至14.7个月。“我们的方法极大地改变了复发的

UT西南医学中心的癌症研究人员报道，在一个结合立体定向放射治疗与特定的化疗方案临床试验中，IV期肺癌患者的生存率增加了一倍多。 相比单用厄洛替尼治疗的仅仅6 - 9个月的生存时间，名为SBRT的体部立体定向放射治疗与化疗药厄洛替尼的结合，能够提高总生存时间至20个月。这种联合治疗能够延长患者无进展生存期，使相似的肺癌患者无进展生存期从以前的2-4个月延长至14.7个月。 “我们的方法极大地改变了复发的模式。我们看到的是在复发、转移方面的改变，”Annette Simmons立体定向治疗中心的主任、 UT西南医学中心的放射肿瘤学副主席、资深作者Dr. Robert Timmerman说，“这种转变导致癌症患者的经过更长时间才会再次出现肿瘤。” 据国家癌症研究所统计，在2014年期间估计有224210名男性和女性诊断为肺癌。来自2004年10月的数据显示，肺癌的五年相对生存率仍然较低，只有16.8%。而在这些癌症病例中，约有85%属于非小细胞肺癌的范畴。 这项II期临床试验包括24例IV期非小细胞肺癌（NSCLC）的癌症患者，他们在接受初始治疗期间即出现肿瘤的继续扩散。该研究的第一

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    2016-07-20 yde2801fm***3926(暂无匿称)

    继续学习中

    0

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    2015-11-11 xue8609

    #立体定向放射治疗#

    0

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    2015-08-23 lidong40

    #JCO#

    0

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    2015-02-02 klivis

    #立体定向#

    0

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    2015-02-05 liao1632

    #定向#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=93829, encodeId=49339382960, content=继续学习中, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210630/bd34754d3b0046c2bd64321e47863622/81281d26ab254ed9803ad3323b1a5f2a.jpg, createdBy=0d5f1677558, createdName=yde2801fm***3926(暂无匿称), createdTime=Wed Jul 20 15:29:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634360, encodeId=e10616343606a, content=<a href='/topic/show?id=5cd0e56034c' target=_blank style='color:#2F92EE;'>#立体定向放射治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75603, encryptionId=5cd0e56034c, topicName=立体定向放射治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98a622156602, createdName=xue8609, createdTime=Wed Nov 11 22:32:00 CST 2015, time=2015-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891159, encodeId=3555189115961, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Aug 23 11:32:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986474, encodeId=5be019864e401, content=<a href='/topic/show?id=160be5596d3' target=_blank style='color:#2F92EE;'>#立体定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75596, encryptionId=160be5596d3, topicName=立体定向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Mon Feb 02 10:32:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1768985, encodeId=43611e68985e9, content=<a href='/topic/show?id=d7674593e05' target=_blank style='color:#2F92EE;'>#定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45937, encryptionId=d7674593e05, topicName=定向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920637977772, createdName=liao1632, createdTime=Thu Feb 05 14:32:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990537, encodeId=55a6199053e56, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu May 07 21:32:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13833, encodeId=36d313833c9, content=很好的文章，阐述了新的观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 20:41:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256501, encodeId=2bdc1256501c4, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Tue Jan 06 13:32:00 CST 2015, time=2015-01-06, status=1, ipAttribution=)]
    2015-05-07 gds2009

    #肺癌患者#

    0

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    2015-01-10 zczcz6655

    很好的文章，阐述了新的观点

    0

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    2015-01-06 guoyibin

    #生存率#

    0

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　　 　　Frederik Wenz教授 　　9月3-4日，第3届中德肺癌论坛在上海举行。在为期两天的论坛中，数十位国内外知名肺癌专家对2011年全球肺癌领域的学术热点、难点进行年度盘点，并和与会人士展开全面的交流和讨论。 　　德国曼海姆大学Frederik Wenz教授介绍了立体定向放疗在肺癌治疗中的进展。 　　杜克大学在20世纪90年代的经验提示，在非小细胞肺癌（N