JASN:AKI住院后死亡原因分析!

2017-12-16 xing.T MedSci原创

总之,在AKI患者中癌症相关死亡与心血管死亡一样常见,而且癌症相关死亡的发生率比一般人群要高。因此,需要策略来照顾和指导那些经历过AKI的癌症患者。

急性肾损伤(AKI)的死亡率很高,但死亡原因尚未得到很好的描述。

近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,为了更好地了解AKI患者住院后死亡的原因,并确定与死亡相关的患者和医院因素,研究人员对加拿大安大略市的居民进行了一项基于人群的研究,这些患者在2003年至2013年期间进行了AKI住院治疗。研究人员利用关联管理数据库,将出院后一年内的死亡原因分为心血管病、癌症、感染等,并计算了标准化死亡率以及比较AKI幸存者与一般成年人群的死亡原因,同时使用Cox比例风险模型估计死亡的决定因素。

该研究纳入了156690例患者,其中43422例(28%)患者在随后一年内死亡。最常见的死亡原因是心血管疾病(28%)和癌症(28%),其标准化死亡率高于一般人群接近六倍(5.81,95%可信区间(95%CI)为5.70至5.92)和八倍(7.87,95%CI为7.72至8.02)。标准化死亡率最高分别为膀胱癌(18.24,95%CI为17.10至19.41)、妇科癌症(16.83,95%CI为15.63至18.07)以及白血病(14.99,95%CI为14.16至15.85)。随着年龄的增长和入住疗养院,癌症和化疗与1年死亡率密切相关。

总之,在AKI患者中癌症相关死亡与心血管死亡一样常见,而且癌症相关死亡的发生率比一般人群要高。因此,需要策略来照顾和指导那些经历过AKI的癌症患者。

原始出处:


Samuel A. Silver,et al. Causes of Death after a Hospitalization with AKI.JASN,2017, http://jasn.asnjournals.org/content/early/2017/12/14/ASN.2017080882.abstract

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    2018-09-22 chenhongpeng
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    2017-12-16 1e131038m59(暂无匿称)

    学习了

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