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罗氏的抗病毒药物在PhIII试验中达标

2018-07-17 MedSci MedSci原创

罗氏的抗病毒药物baloxavirmarboxil
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罗氏公司表示，其研发的流感药物baloxavir marboxil已经获得了日本Shionogi的许可，在后期试验中达到了关键目标。来自第三阶段CAPSTONE-2研究的数据，该研究评估了流感并发症高风险人群的抗病毒药物，与安慰剂相比，在改善流感症状的主要终点时表现出更高的疗效。与安慰剂和奥司他韦相比，Baloxavir marboxil在一系列次要终点（包括病毒脱落和降低体内病毒水平）方面也表现



罗氏公司表示，其研发的流感药物baloxavir marboxil已经获得了日本Shionogi的许可，在后期试验中达到了关键目标。

来自第三阶段CAPSTONE-2研究的数据，该研究评估了流感并发症高风险人群的抗病毒药物，与安慰剂相比，在改善流感症状的主要终点时表现出更高的疗效。

与安慰剂和奥司他韦相比，Baloxavir marboxil在一系列次要终点（包括病毒脱落和降低体内病毒水平）方面也表现出卓越的疗效，并且还显着降低了流感相关并发症的发生率。

该公司还表示，值得注意的是，该药物耐受性良好，没有发现任何安全信号。

"Baloxavir marboxil是第一种抗病毒药物，对那些最容易感染流感并发症的人，包括老年人和那些有一定医疗条件的人来说，具有临床意义，"罗氏首席医疗官、全球产品开发主管桑德拉·霍宁(Sandra Horning)说。

"我们计划向医疗保健机构提交第二次三期药物研究的阳性结果，并期待讨论下一步措施，因为目前没有批准专门用于治疗这一高危人群的抗病毒药物。"

结果将在即将举行的医学会议上公布。


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    2018-08-20 wmr111

    #III试验#

    0

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    2018-10-07 juliusluan78

    #III#

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-19 yahu

    #抗病毒#

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-19 yangshch

    #抗病毒药物#

    0

  5. 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    2018-07-19 jihuaijun1112

    学习学习学习

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 kafei

    学习了谢谢

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 zb1235672

    学习了

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Jul 18 10:19:58 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332405, encodeId=ebcd332405b8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Wed Jul 18 08:55:35 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332398, encodeId=b17d332398b8, content=真正治疗流感的药物学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 liumin1987

    真正治疗流感的药物学习了

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 神功盖世

    阅

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 yjs木玉

    学习学习再学习

    0

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