中国循环杂志:郑大一院学者研究显示,多索茶碱可有效治疗替格瑞洛所致呼吸困难,且不影响抗血小板效应

2017-11-02 卢芳 中国循环杂志

随着替格瑞洛在临床的广泛应用,与其相关的呼吸困难也越来越引起关注。近期郑州大学附属第一医院韩战营等研究发现,对于这类患者给予多索茶碱治疗呼吸困难有效,而且不影响替格瑞洛抗血小板聚集作用。

随着替格瑞洛在临床的广泛应用,与其相关的呼吸困难也越来越引起关注。近期郑州大学附属第一医院韩战营等研究发现,对于这类患者给予多索茶碱治疗呼吸困难有效,而且不影响替格瑞洛抗血小板聚集作用。

研究显示,应用多索茶碱1天后,93%的患者呼吸困难明显缓解,远远高于安慰剂组的63%。而且治疗前后,血小板聚集率与安慰剂相似。

此外,在随访半年时,服用多索茶碱组与安慰剂组心原性死亡、心肌梗死卒中、出血等心血管不良事件的发生率也无差异。

研究者介绍说,替格瑞洛可以使细胞外腺苷水平升高,多索茶碱起效或是由于能对抗腺苷等呼吸道的收缩作用所致,但鉴于仍有部分患者呼吸困难未缓解,其中机制尚需进一步研究。

该研究共纳入服用替格瑞洛后出现相关呼吸困难的冠心病患者172人,其中86人早晚给予多索茶碱片各1片,服用5天;余者均为对照,给予安慰剂治疗。

原始出处:
刘亚梅,韩战营, 王徐乐, 等. 多索茶碱治疗替格瑞洛相关呼吸困难的安全性和有效性分析. 中国循环杂志, 2017, 32: 886-888.

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    2017-11-04 hbwxf
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    2017-11-02 明天会更好!

    很不错.学习了.值得分享!

    0