Intern Med J:心脏选择性β受体阻断剂治疗COPD急性加重安全吗?

2017-10-24 顾歆纯 环球医学

新的证据表明,启用心脏选择性β受体阻断剂可以让慢性阻塞性肺疾病(COPD)合并心血管疾病的患者获益。2017年,发表在《Intern Med J》的一项研究调查了住院期间启用心脏选择性β受体阻断剂治疗COPD急性加重患者的安全性。结果表明,COPD急性加重期间启用心脏选择性β受体阻断剂的耐受性似乎较好。

新的证据表明,启用心脏选择性β受体阻断剂可以让慢性阻塞性肺疾病(COPD)合并心血管疾病的患者获益。2017年,发表在《Intern Med J》的一项研究调查了住院期间启用心脏选择性β受体阻断剂治疗COPD急性加重患者的安全性。结果表明,COPD急性加重期间启用心脏选择性β受体阻断剂的耐受性似乎较好。

目的:考察住院期间启用β受体阻断剂治疗COPD急性恶化的安全性。

方法:在两家三级医院开展为期12个月,纳入1071例因COPD急性恶化住院患者的回顾性队列研究。研究者鉴别出36例在住院期间启用β受体阻断剂治疗的患者。主要结局指标是评价启用β受体阻断剂治疗相关的心血管和呼吸不良事件。

结果:β受体阻断剂最常见的适应症为房颤(53%)和急性冠脉综合征(36%)。在启用β受体阻断剂后,没有患者出现呼吸功能临床显着降低,包括呼吸症状恶化、需要氧、支气管扩张或通气。这些结果在患有可逆的气道疾病和晚期COPD患者中是可论证的。仅有1例患者(2.8%)在治疗后48 h出现症状性低血压。

结论:COPD急性加重期间启用心脏选择性β受体阻断剂的耐受性似乎较好。

原始出处:
Neef PA, Burrell LM, McDonald CF,et al.Commencement of cardioselective beta-blockers during hospitalisation for acute exacerbations of chronic obstructive pulmonary disease.Intern Med J. 2017 Sep;47(9):1043-1050. doi: 10.1111/imj.13518.

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    2018-04-13 871538379

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    2017-11-02 杏林一叶

    过去β受体阻断剂是COPD的禁忌症.现在.国内外指南都肯定了其应用于合并心衰的COPD病人获益..

    0

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    2017-10-24 清风拂面

    谢谢分享.学习了

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