Chest:收缩压及心率等指标可预测肺动脉高压患者的预后

2013-08-19 sd3212 dxy

作为一个19元公式的一部分,心率(HR)与收缩压(SBP)是预测肺动脉高压(PAH)患者生存重要的多变量预测因子。但作为独立预测因子,HR和BP对PAH患者生存率及将来入院情况的预测价值目前仍不清楚。为此,来自美国洛杉矶市美国退伍军人管理局大洛杉矶医疗保健系统、加州大学大卫·格非医学院的Malcolm M. Bersohn等进行了一项研究,研究结果显示,SBP及HR等指标可预测PAH患者的预后。研

作为一个19元公式的一部分,心率(HR)与收缩压(SBP)是预测肺动脉高压(PAH)患者生存重要的多变量预测因子。但作为独立预测因子,HR和BP对PAH患者生存率及将来入院情况的预测价值目前仍不清楚。为此,来自美国洛杉矶市美国退伍军人管理局大洛杉矶医疗保健系统、加州大学大卫·格非医学院的Malcolm M. Bersohn等进行了一项研究,研究结果显示,SBP及HR等指标可预测PAH患者的预后。研究结果在线发表于2013年4月18日的CHEST杂志上。 【原文下载

该研究是一项关于PAH患者预后的前瞻性、观察性研究。研究者对REVEAL注册研究中入选患者的HR、SBP及SBP/HR值等数据进行了五分位数分析,并通过对患者生存率和非住院率的五分位数分析计算出了相应的Kaplan-Meier曲线。

患者入选一年后,其SBP及HR最差的五分位生存率分别为85%±2%及86%±2%;而其SBP/HR最差的五分位生存率及中间第3位五分位生存率分别为84%±2%及91%±1%。受试者的住院率高于死亡率,但二者五分位数分析结果模式相似。随访一年间,患者SBP、HR及SBP/HR变化值(Δ)最差五分位住院率分别为85%±2%、86%±2%、84%±2%,中间第3位五分位住院率分别为91%±1%、90%±1%、90%±1%。

该研究结果表明,SBP及HR等指标可用于预测PAH患者的生存率及预后。与入组或第一次随访时相比,受试者从入组到第一次随访期间生命体征变化值对其死亡率的预测价值较小。入组时的HR、SBP、SBP/HR参数可用于鉴别受试者属于高危还是低危人群。高危与低危人群相比,其生存率及非住院率分别有5%~7%及9%~11%的差异。根据SBP/HR定义的高危人群,可涵盖绝大多数分别依据HR或SBP所定义的高危患者。

原始出处:

Bersohn MM Turner MP Traiger GL Frost AE Shapiro S.Systemic Blood Pressure and Heart Rate as Prognostic Indicators in Pulmonary Arterial Hypertension.Chest 2013 Apr :[] 【原文下载

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