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SCI REP：尿液Endotrophin预测慢性肾脏疾病患者疾病进展！

2017-12-13 xing.T MedSci原创

Endotrophin预测CKD
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由此可见，ECR可预测CKD患者的疾病进展。

肾脏纤维化是慢性肾脏病（CKD）进展的核心致病过程。Ⅳ型胶原（COL VI）在肾脏纤维化中的表达上调。Endotrophin从COL VI中释放出来，具有多种促纤维化作用。肾脏疾病的严重程度有很大差异，提供准确的CKD进展信息可能有助于改善临床决策。近日，Scientific reports杂志上发表了一篇研究文章。研究人员假设尿液中来源于纤维化肾脏COL VI沉积期间的Endotrophin是CKD进展的标志物。
 
肾脏损害和二级护理（RIISC）队列是一个含有499名CKD患者的前瞻性观察性研究。Endotrophin存在于纤维化肾脏COL VI沉积增加的区域，但在组织学上正常的肾脏组织中未出现。尿液中Endotrophin：肌酐比值（ECR）处于第三和第四位四分位数的患者与一年后疾病进展独立相关，在将传统危险因素进行调整后（比值比（95%可信区间）分别为3.68（1.06-12.83）和8.65（2.46-30.49））。
 
此外，将ECR四分位数加入到预测模型中可以提高对疾病进展的预测，其无分类净重分类改善（0.45，95%可信区间为0.16-0.74，P=0.002）和综合判别改善（0.04，95%可信区间为0.02-0.06，P＜0.001）。ECR与终末期肾病（ESRD）的发生发展有关。

由此可见，ECR可预测CKD患者的疾病进展。
 
原始出处：
 
Daniel Guldager Kring Rasmussen,et al. Urinary endotrophin predicts disease progression in patients with chronic kidney disease.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-17470-3
 
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  1. 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07:42:22 CST 2019, time=2019-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358401, encodeId=c43b358401f4, content=好文章大家一起学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Jan 17 07:19:56 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907686, encodeId=5641190e6860c, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2020-04-26 阿菡

    学习了CKD

    0

  2. 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createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2020-04-23 阿菡

    好文章

    0

  3. 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createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2020-04-14 阿菡

    好文章

    0

  4. 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time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381492, encodeId=823f381492f6, content=好资源共同学习进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Apr 09 01:31:32 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373473, encodeId=8d143e34730e, content=真好用, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Oct 03 07:42:22 CST 2019, time=2019-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358401, encodeId=c43b358401f4, content=好文章大家一起学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Jan 17 07:19:56 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907686, encodeId=5641190e6860c, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2020-04-13 阿菡

    学习了，多多分享

    0

  5. 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07:42:22 CST 2019, time=2019-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358401, encodeId=c43b358401f4, content=好文章大家一起学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Jan 17 07:19:56 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907686, encodeId=5641190e6860c, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2020-04-09 阿菡

    好资源共同学习进步

    0

  6. 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07:42:22 CST 2019, time=2019-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358401, encodeId=c43b358401f4, content=好文章大家一起学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Jan 17 07:19:56 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907686, encodeId=5641190e6860c, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2019-10-03 阿菡

    真好用

    0

  7. 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createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2019-01-17 阿菡

    好文章大家一起学习

    0

  8. 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time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381492, encodeId=823f381492f6, content=好资源共同学习进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Apr 09 01:31:32 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373473, encodeId=8d143e34730e, content=真好用, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Oct 03 07:42:22 CST 2019, time=2019-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358401, encodeId=c43b358401f4, content=好文章大家一起学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Jan 17 07:19:56 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907686, encodeId=5641190e6860c, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2018-06-13 mjldent

    #疾病进展#

    0

  9. 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07:42:22 CST 2019, time=2019-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358401, encodeId=c43b358401f4, content=好文章大家一起学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Jan 17 07:19:56 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907686, encodeId=5641190e6860c, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2017-12-24 hmwwww

    #疾病患者#

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381687, encodeId=82bd38168ec0, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Tue Apr 14 06:53:10 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381651, encodeId=7046381651f3, content=学习了，多多分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Mon Apr 13 11:50:24 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381492, encodeId=823f381492f6, content=好资源共同学习进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Apr 09 01:31:32 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373473, encodeId=8d143e34730e, content=真好用, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Oct 03 07:42:22 CST 2019, time=2019-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358401, encodeId=c43b358401f4, content=好文章大家一起学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Thu Jan 17 07:19:56 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907686, encodeId=5641190e6860c, content=<a href='/topic/show?id=fdcee0731d2' target=_blank style='color:#2F92EE;'>#疾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70731, encryptionId=fdcee0731d2, topicName=疾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Wed Jun 13 10:57:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799022, encodeId=754c1e99022ec, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Dec 24 01:57:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316586, encodeId=b56931658669, content=希望能早日临床应用就好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b11d1611818, createdName=doctorzyp, createdTime=Sat May 19 09:40:06 CST 2018, time=2018-05-19, status=1, ipAttribution=)]
    2018-05-19 doctorzyp

    希望能早日临床应用就好!

    0

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