Psychother Psychosom:长期服用抗抑郁药物的情况会更糟

2017-10-30 佚名 Medicalxpress

在当前的心理治疗和精神医学研究中,一项新的分析揭示了抗抑郁药物长期疗效的观点。重度抑郁症(MDD)在临床中比在社区样本中更常见或反复出现。例如,也许85%的患者,但只有35%的社区中重度抑郁症患者在15年内经历了另一种抑郁发作。尽管如此,包括抗抑郁药物或认知疗法在内的积极治疗可以减少抑郁症状,并延缓复发。然而,在临床试验中接受治疗和未经治疗的患者的随访时间很少超过1-2年。

在当前的心理治疗和精神医学研究中,一项新的分析揭示了抗抑郁药物长期疗效的观点。重度抑郁症(MDD)在临床中比在社区样本中更常见或反复出现。例如,也许85%的患者,但只有35%的社区中重度抑郁症患者在15年内经历了另一种抑郁发作。尽管如此,包括抗抑郁药物或认知疗法在内的积极治疗可以减少抑郁症状,并延缓复发。然而,在临床试验中接受治疗和未经治疗的患者的随访时间很少超过1-2年。

目前对一个有9年随访的国家样本的分析澄清了这些可能性。对治疗和未经治疗的人使用相同的评估方法排除了第一种可能性。测试MDD的严重程度和广泛的人口统计学、社会心理和临床变量是否对治疗和未治疗的人员之间的长期差异进行了评估,估计了第二种可能性,结果差异更可能是由于治疗而造成的。在1、2和3的调查浪潮中,12个月的MDD流行率分别为13.3、10.5和9.9%。在MDD中,38.1%的参与者没有接受治疗,25.2%的治疗不包括药物治疗,19.2%的治疗没有药物治疗,13.5%的适当治疗包括药物治疗,还有4.1%的治疗在过去一年中没有药物治疗。

先前的抑郁状态,治疗及其相互作用,预示了随后的抑郁症状水平。在重度抑郁症患者中,在治疗不充分、没有药物治疗、没有药物治疗的情况下,症状比不治疗更严重,而且在治疗后出现的症状比没有药物治疗的症状要高。此外,在重度抑郁症患者中,在治疗不充分、治疗不充分或没有治疗的情况下,症状比没有治疗的症状要高,而且在治疗后出现的症状比没有药物治疗的症状要高。

这些发现表明,在治疗后的9年里,症状比没有药物治疗的症状要高得多,而且重度抑郁症的严重程度和其他的协变也没有在药物治疗后出现抑郁的症状。然而,病人的特征在没有药物治疗后就出现了症状。这一模式表明了抗抑郁药的长期治疗效果。

原始出处:
Jeffrey R. Vittengl. Poorer Long-Term Outcomes among Persons with Major Depressive Disorder Treated with Medication, Psychotherapy and Psychosomatics (2017). DOI: 10.1159/000479162

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    2018-01-23 wetgdt
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    2017-10-31 Jackie Li

    学习

    0

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    2017-10-31 sunfeifeiyang

    是药三分毒

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1722472, encodeId=44f11e22472bc, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Jan 23 06:03:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446690, encodeId=854d14466905c, content=<a href='/topic/show?id=38bf553405a' target=_blank style='color:#2F92EE;'>#抗抑郁药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55340, encryptionId=38bf553405a, topicName=抗抑郁药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4bd5278649, createdName=huhuaidong389, createdTime=Wed Nov 01 09:03:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492197, encodeId=a6ef149219e65, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Wed Nov 01 09:03:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257550, encodeId=2c1025e550bf, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Tue Oct 31 17:29:09 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257413, encodeId=602025e4139f, content=是药三分毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Tue Oct 31 07:18:47 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257293, encodeId=ee0625e29335, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Mon Oct 30 21:07:30 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2017-10-30 changjiu

    学习了.谢谢

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