Obstet Gynecol:试管婴儿孕中期自然流产的危险因素

2015-03-06 Mechront MedSci原创

Leah Hawkins Bressler等人对2001-2012年间、年龄21-44岁、行试管婴儿(IVF-ET术后)、怀孕至12周经胎心音确定至少有一活胎的女性进行了一项回顾性队列研究分析,以探究非子宫畸形条件下,IVF-ET术后,孕中期自然流产的危险因素。其研究成果发表在近期《Obstet Gynecol》上。研究者们对参与者解剖结构正常的子宫进行全面系统的评估



Leah Hawkins Bressler等人对2001-2012年间、年龄21-44岁、行试管婴儿(IVF-ET术后)、怀孕至12周经胎心音确定至少有一活胎的女性进行了一项回顾性队列研究分析,以探究非子宫畸形条件下,IVF-ET术后,孕中期自然流产的危险因素。其研究成果发表在近期《Obstet Gynecol》上。

研究者们对参与者解剖结构正常的子宫进行全面系统的评估,并且统计孕中期自然流产(12+1周至23+6周)情况,同时充分评估孕妇情况和该流产的临床特点。运用多因素回归分析得到调整后OR值。

该研究结果显示,纳入人群中,有60名(2.1%)孕妇发生了孕中期自然流产,剩下2,841名(97.9%)孕妇成功娩出活胎。根据其妊娠情况和临床特点,进行多因素回归分析得出:1)双胎或多胎比单胎更容易孕中期自然流产,aOR=1.93,95% CI 1.15-3.24,P=0.01;且孕中期自然流产组里双胎或多胎所占比例更大,为48.3%,而在活产组占34.1%。2)子宫肌瘤使孕中期自然流产风险增加了近4倍,OR=3.82,95% CI 1.85-7.89,P<0.001;子宫肌瘤在自然流产组里占16.7%,在活产组占4.7%。3)肥胖BMI≥30较正常BMI其孕中期自然流产风险增加2倍多,OR=2.38,95% CI 1.05-5.65,P=0.04;其在流产组占32%,活产组占16.5%。4)其余如IVF治疗参数、孕妇年龄、种族和反复流产史等不增加孕中期自然流产风险。

该研究表明,双胎或多胎、子宫肌瘤和肥胖会增加IVF-ET术后孕妇孕中期自然流产风险。

原始出处:

Leah Hawkins Bressler,et al.Factors Associated With Second-Trimester Pregnancy Loss in Women With Normal Uterine Anatomy Undergoing In Vitro Fertilization.Obstet Gynecol 2015;125:621–7

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    2015-04-15 yhy100200
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    2016-01-24 ying_wu
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    2015-03-09 MedSci客户端网友

    赞!!!

    0

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    2015-03-09 183.227.43.**

    珍贵儿…

    0

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    2015-03-08 lovetcm

    这么高

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    2015-03-07 xiaoai5777

    yaokam原文

    0

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