Front Physiol:不可忽视,牙周炎还与炎症性贫血相关!

2020-04-06 MedSci原创 MedSci原创

牙周炎是一种可能具有传染性的慢性炎症性疾病。各种慢性疾病中发生的炎症性贫血(AI)会改变血红蛋白(Hb)浓度和铁的状态。目前,牙周炎与AI之间的关联性仍有争议。本研究旨在评估有或没有牙周炎的患者血液学

牙周炎是一种可能具有传染性的慢性炎症性疾病。各种慢性疾病中发生的炎症性贫血(AI)会改变血红蛋白(Hb)浓度和铁的状态。目前,牙周炎与AI之间的关联性仍有争议。本研究旨在评估有或没有牙周炎的患者血液学参数和铁代谢指标水平的变化。

 

对电子数据库(MEDLINE、EMBASE和Cochrane)进行了搜索,以确定有关贫血和牙周炎的出版物。使用STATA 12.1对性别、牙周炎程度和样本量进行了亚组分析。

 

结果共纳入了16项研究。汇总结果显示,Hb[标准化均值差异(SMD)=-0.76,95%CI=(-1.15,-0.37)]、红细胞[SMD=-0.69,95%CI=(-1.09,-0.29)]、血红蛋白[SMD=-1.13,95%CI=(-1.69,-0. 57)]、平均冠状体容积[SMD =-0.16,95% CI =(-0.32,-0.01)]、平均冠状体Hb[SMD =-0.16,95% CI =(-0.28,-0.04)]下降,但红细胞沉降率[SMD = 0.63,95% CI =(0.06,1.19)]上调。此外,牙周炎患者具有有较高的血红蛋白水平[SMD = 0.59,CI =(0.05,1.12)]和较低的转铁蛋白水平[SMD =-4.6,CI =(-13.1,-3.90)],异质性较高。

 

总之,本荟萃分析表明,牙周炎会降低Hb浓度,扰乱铁代谢平衡,这证实了牙周炎与AI的发展倾向之间的关联强度,尤其是重度牙周炎。未来仍需要更多的无偏倚的队列研究和更大样本量的研究,才能做出准确的判断。

 

原始出处:

 

Donglei WuZhengshen Lin, et al., Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis. Front Physiol. 2019; 10: 1620.

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