Anesthesiology:谵妄是否会增加术后死亡风险?

2017-05-11 tianxuexin MedSci原创

谵妄是一种急性可逆性的老年综合征,表面大脑功能失代偿。 谵妄可能会导致术后不良结局,但是有关谵妄是否是增高死亡率的独立预测因素存在争议。因此,研究人员评估了成人非心脏手术患者术后谵妄和死亡率之间的相关性。使用Cochrane,MEDLINE / PubMed,“护理和联合健康文献累积指数”以及Embase等数据库进行了系统的搜索。两名独立评审员进行了筛选和数据提取。用随机效应模型计算的汇总效应估计

谵妄是一种急性可逆性的老年综合征,表面大脑功能失代偿。 谵妄可能会导致术后不良结局,但是有关谵妄是否是增高死亡率的独立预测因素存在争议。因此,研究人员评估了成人非心脏手术患者术后谵妄和死亡率之间的相关性。

使用Cochrane,MEDLINE / PubMed,“护理和联合健康文献累积指数”以及Embase等数据库进行了系统的搜索。两名独立评审员进行了筛选和数据提取。用随机效应模型计算的汇总效应估计值表示为95%CI的优势比。使用Cochrane非随机研究偏倚工具风险评估偏倚风险。

共有4,968份被引用的引文中有34篇符合纳入标准。偏倚风险从中度到重要。未调整事件发生率的汇总分析(5,545例)表明,谵妄使得死亡率增加了四倍(优势比= 4.12 [95%CI,3.29-5.17],I2 = 24.9%)。由于所报告的影响措施的异质性,对调整后的结果进行正式的汇总分析是不可能的。然而,在控制预先指定的混杂因素的研究中,平均随访21个月后,没有发现术后谵妄与死亡率(髋关节骨折的两项研究; n = 729)之间有统计学意义的关联。总体而言,随着偏倚研究风险的降低,谵妄与死亡率之间的关联性下降。

很少有高质量的研究可以估计谵妄对术后死亡率的影响。控制预先指定的混杂因素的研究没有表明谵妄与死亡率存在显着独立关联。

原始出处:

Gavin M. Hamilton, et al. A Systematic Review and Meta-analysis Examining the Impact of Incident Postoperative Delirium on Mortality. Anesthesiology Newly Published on May 4, 2017. doi:10.1097/ALN.0000000000001660

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    2019-07-09 小微940490

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    2019-07-01 小微940490

    mark

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    2017-05-18 zhanjian

    谵妄与死亡率之间本来无必然联系,谵妄只是暂时的脑功能失调,死亡与疾病本身的严重程度有关吧。

    0

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    2017-05-14 semrour

    这么说不必太在意瞻望咯?

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=369346, encodeId=340a3693469f, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=526e2567988, createdName=小微940490, createdTime=Tue Jul 09 09:22:30 CST 2019, time=2019-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368791, encodeId=57d8368e91f6, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=526e2567988, createdName=小微940490, createdTime=Mon Jul 01 22:20:49 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050678, encodeId=90d620506e8ca, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Thu Jun 29 07:13:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199592, encodeId=9cc3199592bc, content=谵妄与死亡率之间本来无必然联系,谵妄只是暂时的脑功能失调,死亡与疾病本身的严重程度有关吧。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJEbELichYe0iahvg8tAHxfKJxBQLrshYz7Lgkjtyd5cawyZV0oMh9V5N04nglicFOtfmFrE6PUA0VS/0, createdBy=f15b2008164, createdName=zhanjian, createdTime=Thu May 18 12:19:51 CST 2017, time=2017-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198005, encodeId=0365198005c6, content=这么说不必太在意瞻望咯?, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cabb1969833, createdName=semrour, createdTime=Sun May 14 13:45:11 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255633, encodeId=2034125563329, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat May 13 00:13:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588240, encodeId=2290158824057, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat May 13 00:13:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196623, encodeId=d58119662340, content=谵妄与死亡率关联性研究,学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu May 11 12:19:14 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-13 skhzy
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    2017-05-11 1e0f8808m18(暂无匿称)

    谵妄与死亡率关联性研究,学习。

    0

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