Lancet Gastroent Hepatol:运动障碍患者进食速度、吞咽频率以及食管收缩之间的关系

2017-07-04 zhangfan MedSci原创

研究结果比较了运动障碍患者以及健康志愿者咽吞和食管运动的差异:健康人群进食速度的影响因素是咽吞频率而非食管收缩力,运动障碍患者则恰恰相反

人们在健康或患病时如何进食的决定因素目前还没有确定。近日研究人员采用高分辨率测压法(HRM)评估健康志愿者和运动障碍患者进食固体膳食餐(STM)时的咽吞咽和食管运动。

研究在苏黎世大学医院开展。健康志愿者进行HRM测试-采取卧位和直立位完成10次水吞咽(SWS),之后直立位进食200g大米固体膳食餐。研究期间,考察患者的咽吞咽时间和食管收缩差异以及可能与饮食速度相关的因素,包括年龄,性别,体重指数,运动障碍情况等并比较水吞咽与固体吞咽测试结果的差异。

研究招募了72名志愿者、54名运动障碍患者以及53吞咽困难但无严重运动障碍患者。研究发现健康志愿者与病人进餐期间,食管运动和进食速度差异显著。吞咽时间的增加伴随着更有效的食管收缩。(健康人群中,<4 s吞咽间隔其有效吞咽仅5%,但>11 s的吞咽间隔其有效吞咽为65%)。健康志愿者很少存在阻塞、痉挛,或过收缩吞咽。相比于健康志愿者,运动障碍患者进食速度慢(14.95g/min vs 32.9g/min)并且患者完成STM测试后出现病理性食管运动复发。对于健康人群,进食速度仅与吞咽频率相关,但对于运动障碍患者进食速度取决于有效食管收缩频率。研究发现高分辨率测压水吞咽法与大米固体膳食餐法的诊断一致性较高 (r=0.81,95% CI 0.74-0.87,p<0.0001)。

研究结果比较了运动障碍患者以及健康志愿者咽吞和食管运动的差异:健康人群进食速度的影响因素是咽吞频率而非食管收缩力,运动障碍患者则恰恰相反。

原始出处:


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    2018-01-23 howi
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    2017-11-25 许安
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jul 04 12:39:51 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1829053, encodeId=9d1f182905396, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 23 15:21:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820905, encodeId=5064182090502, content=<a href='/topic/show?id=9e651010e830' target=_blank style='color:#2F92EE;'>#食管收缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101078, encryptionId=9e651010e830, topicName=食管收缩)], attachment=null, authenticateStatus=null, 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href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jul 06 01:21:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437215, encodeId=8fe4143e2156c, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jul 04 12:39:51 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1829053, encodeId=9d1f182905396, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 23 15:21:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820905, encodeId=5064182090502, content=<a href='/topic/show?id=9e651010e830' target=_blank style='color:#2F92EE;'>#食管收缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101078, encryptionId=9e651010e830, topicName=食管收缩)], attachment=null, authenticateStatus=null, 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href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jul 06 01:21:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437215, encodeId=8fe4143e2156c, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 06 01:21:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585116, encodeId=64c915851169c, content=<a href='/topic/show?id=625c9440e39' target=_blank style='color:#2F92EE;'>#进食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94407, encryptionId=625c9440e39, topicName=进食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94cc17130334, createdName=gj0737, createdTime=Thu Jul 06 01:21:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218494, encodeId=f8e521849444, content=谢谢分享,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jul 04 12:39:51 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-06 gwc384
  7. 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href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jul 06 01:21:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437215, encodeId=8fe4143e2156c, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jul 04 12:39:51 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-06 zhouqu_8
  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jul 04 12:39:51 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-06 gj0737
  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jul 04 12:39:51 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 清风拂面

    谢谢分享,受益匪浅

    0

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