Neurology:帕金森运动障碍类型的基线预测

2017-06-12 zhangfan MedSci原创

大部分帕金森患者基线运动障碍特征可预测其疾病进展导致的运动障碍,该研究对帕金森的临床治疗具有一定的指导作用

近日研究人员对帕金森患者基线运动障碍特征对帕金森进展后运动功能的影响进行了研究。

在早前的研究中,研究人员通过对166例PD患者的研究确定了3种帕金森运动障碍亚型:震颤为主、少动-强直及混合型。本次研究在早前研究的基础上收纳了10例患病15年以上的患者。对患者基线水平的震颤相对严重度、运动徐缓或运动障碍以及僵直程度进行评估。

研究发现最常见的运动障碍亚型为混合型、之后是少动-强直及震颤。有7名患者在基线时未服用抗帕金森药物。所有患者中的85%以及未治疗患者的91%其疾病进展运动障碍亚型在基线时既可以预测。在3种亚型中,混合型以及少动-强直型患者预测的敏感性、特异性以及阳线预测率较高,但震颤型预测效果不佳。

研究认为对于大部分帕金森患者基线运动障碍特征可预测其疾病进展导致的运动障碍,该研究对帕金森的临床治疗具有一定的指导作用。

原始出处:

Ali H. Rajput et al. Baseline motor findings and Parkinson disease prognostic subtypes. Neurology. June 7 2017.

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    2018-01-08 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=1999978, encodeId=d8c219999e88a, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Jan 08 01:00:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368785, encodeId=436d1368e85d3, content=<a href='/topic/show?id=b40b9423884' target=_blank style='color:#2F92EE;'>#运动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94238, encryptionId=b40b9423884, topicName=运动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Wed Jun 14 01:00:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209813, encodeId=4a16209813f8, content=非常好的文章,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Mon Jun 12 12:10:15 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209808, encodeId=1632209808b1, content=这个研究很有意义,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=a7ea2070227, createdName=158****8818, createdTime=Mon Jun 12 11:41:15 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209793, encodeId=cafe209e93d8, content=学习了不少事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Mon Jun 12 10:19:56 CST 2017, time=2017-06-12, status=1, ipAttribution=)]
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    2017-06-12 1e0f8808m18(暂无匿称)

    非常好的文章,学习了。

    0

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    2017-06-12 158****8818

    这个研究很有意义,值得学习

    0

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    2017-06-12 圣艮山

    学习了不少事情

    0

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