Hepatology:咀嚼茶叶也会增加慢性肝病的风险?

2018-02-03 MedSci MedSci原创

Catha edulis(khat,阿拉伯茶)的叶子的咀嚼已经涉及到肝脏疾病的发展,但是,目前尚没有进行可控的观察研究。近期,一项发表在杂志Hepatology上的研究旨在确定咀嚼茶(khat)是否与慢性肝病(CLD)的发展有关。 研究者们自2015年4月至2016年4月在埃塞俄比亚哈拉尔的两所公立医院进行了一项病例对照研究。连续抽样了150例成人CLD患者作为病例组,300名无CLD临

Catha edulis(khat,阿拉伯茶)的叶子的咀嚼已经涉及到肝脏疾病的发展,但是,目前尚没有进行可控的观察研究。

近期,一项发表在杂志Hepatology上的研究旨在确定咀嚼茶(khat)是否与慢性肝病(CLD)的发展有关。 

研究者们自2015年4月至2016年4月在埃塞俄比亚哈拉尔的两所公立医院进行了一项病例对照研究。连续抽样了150例成人CLD患者作为病例组,300名无CLD临床或实验室证据的人群被列为对照组。Khat的消费以khat年量化;一个khat年的定义是:每日使用200克khat鲜果,为期一年。使用逻辑回归模型控制混杂因素。

研究结果显示:咀嚼khat与发展CLD的风险之间存在显着相关性(粗比值比[OR] 2.64; 95%CI 1.56-4.58)。在男性中,调整年龄、酒精使用和慢性乙型/丙型肝炎感染后,这种风险随着khat暴露的增加而增加;因此,与从未咀嚼过的人群相比,低khat暴露的校正OR为3.58(95%CI 1.05-12.21),中khat暴露为5.90(95%CI 1.79-19.44),高khat暴露为13.03(95%CI 3.61-47.02) 。此外,此项研究结果在事后敏感性分析中是稳健的,其中具有可识别的CLD危险因素的个体被排除在外。

此项研究结果发现了在咀嚼khat和发展CLD的风险之间存在显着的相关性。在男性中,该相关性较强并且是剂量依赖性的,这也表明了两者之间具有一定的因果关系。随着世界范围内咀嚼khat的普及,此项研究发现对公众健康可能有重大影响。

原始出处:
Orlien SMS, Sandven I, et al. Khat chewing increases the risk for developing chronic liver disease: A hospital-based case-control study. Hepatology. 2018 Jan 25. doi: 10.1002/hep.29809.

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    2018-05-10 Boyinsh
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    2018-02-05 hbwxf
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    2018-02-05 gwc384
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    2018-02-03 131****1460

    学习了受益匪浅

    0

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    2018-02-03 1e0f8808m18(暂无匿称)

    学习了.谢谢分享

    0