Diabetes Care:根据血糖状态和高血糖合并症评估痴呆风险

2021-12-22 MedSci原创 MedSci原创

轻度高血糖和合并症与痴呆发生相关。医务人员可以考虑在慢性疾病的前期(例如糖尿病前期)进行干预以预防痴呆症。

人口快速老龄化使得预防和治疗痴呆症变得更加重要。目前,针对痴呆症没有治愈性的手段,可改变的危险因素(例如肥胖、高血压糖尿病、血脂异常)对痴呆症风险的贡献正成为预防痴呆症的一个重要问题。在这些危险因素中,糖尿病一直被证明与痴呆风险增加相关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在根据空腹血糖水平和合并症的有无来调查痴呆的发生风险。

研究人员使用健康保险索赔数据库和韩国每两年一次的健康检查结果,选择了8400950名40岁以上的受试者,他们在2009-2010年期间接受了健康检查。研究人员一直随访受试者至2016年。受试者的基线特征根据是否存在糖尿病(是/否)和血糖状态分类为血糖正常、空腹血糖受损(IFG)、新发糖尿病或已患糖尿病(病程<5年或≥5年)。研究人员估计了每个类别受试者痴呆发生的调整风险比(aHR)。

在48323729人次每年的观察期内,353392名(4.2%)受试者发生了全因痴呆。与正常血糖相比,IFG中的aHR(95%CI)为1.01(1.01-1.02),新发糖尿病为1.45(1.44-1.47),患糖尿病<5年为1.32(1.30-1.33),以及患糖尿病≥5年1.62(1.60-1.64)。研究人员发现缺血性心脏病和慢性肾病与痴呆症之间的关联受到有无糖尿病的影响。与糖尿病相比,缺血性卒中与痴呆之间的相关性更大。

由此可见,轻度高血糖和合并症与痴呆发生相关。医务人员可以考虑在慢性疾病的前期(例如糖尿病前期)进行干预以预防痴呆症。

原始出处:
 
Woo Jung Kim,et al.Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study.Diabetes care.2021.https://diabetesjournals.org/care/article/doi/10.2337/dc21-0957/138990/Risk-of-Incident-Dementia-According-to-Glycemic

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createdBy=5f1f5633705, createdName=ms1000000251410274, createdTime=Fri Dec 24 19:36:12 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1083949, encodeId=3a241083949b3, content=血糖管理很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cf71371794, createdName=weili41248, createdTime=Fri Dec 24 16:12:28 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261226, encodeId=3afb1261226c2, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, 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  5. 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encryptionId=0da289844bc, topicName=血糖状态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeed21545240, createdName=naiwu84, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=)]
    2021-12-26 烧焦的茄子丶

    学习了

    0

  6. 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encryptionId=0da289844bc, topicName=血糖状态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeed21545240, createdName=naiwu84, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=)]
    2021-12-24 ms1000000251410274

    控糖预防老年痴呆

    0

  7. 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createdBy=55ce62, createdName=hbwxf, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316818, encodeId=4d01131681834, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630642, encodeId=e9f9163064247, content=<a href='/topic/show?id=0da289844bc' target=_blank style='color:#2F92EE;'>#血糖状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89844, encryptionId=0da289844bc, topicName=血糖状态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeed21545240, createdName=naiwu84, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=)]
    2021-12-24 weili41248

    血糖管理很重要

    0

  8. 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createdBy=5f1f5633705, createdName=ms1000000251410274, createdTime=Fri Dec 24 19:36:12 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1083949, encodeId=3a241083949b3, content=血糖管理很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cf71371794, createdName=weili41248, createdTime=Fri Dec 24 16:12:28 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261226, encodeId=3afb1261226c2, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316818, encodeId=4d01131681834, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630642, encodeId=e9f9163064247, content=<a href='/topic/show?id=0da289844bc' target=_blank style='color:#2F92EE;'>#血糖状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89844, encryptionId=0da289844bc, topicName=血糖状态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeed21545240, createdName=naiwu84, createdTime=Fri Dec 24 10:45:55 CST 2021, time=2021-12-24, status=1, ipAttribution=)]
    2021-12-24 hbwxf
  9. 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  10. [GetPortalCommentsPageByObjectIdResponse(id=1902679, encodeId=6e9419026e98e, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon May 16 08:45:55 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761805, encodeId=dcb11e618059b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, 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