JAHA:相位角可作为虚弱和术后死亡率的生物标志物

2018-08-23 xiangting MedSci原创

低 PA与虚弱相关,并可以预测重大心脏手术后的死亡率、发病率和住院时间。

相位角(PA)是一种生物阻抗指标,由瘦体重和水合状态决定。PA值低的患者更容易出现虚弱、肌肉萎缩或营养不良。既往研究表明低PA可以预测心脏手术后的不良结局,但该情况下PA对生存率的影响尚未得到评估。

BICS研究(心脏外科生物阻抗)招募了277例在加拿大魁北克省蒙特利尔两所大学附属医院接受重大心脏手术的患者。术前进行生物阻抗测量以及虚弱和营养评估。主要结局是全因死亡率。次要结局是30天死亡率、术后发病率和住院时间。随访1个月时有10例死亡,12个月时有16例死亡。PA与年龄、性别、体重指数、合并症和由短体能电池和弗雷德量表所测量的虚弱相关。在调整胸外科医师协会预测的死亡率后,PA较低与1个月死亡率较高(PA每减少1°调整后的比值比为3.57;95%置信区间,1.35-9.47)、12个月死亡率较高(PA每减少1°,调整后的比值比3.03;95%置信区间,1.30-7.09)、总发病风险较高(PA每减少1°,调整后的风险比2.51;95%置信区间,1.32-4.75),和住院时间较长(PA每减少1°,调整后的β, 4.8天;95%置信区间,1.3-8.2天)相关。

低 PA与虚弱相关,并可以预测重大心脏手术后的死亡率、发病率和住院时间。未来需要进一步的研究来确定PA对旨在改善虚弱治疗措施的反应能力。

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    2019-02-05 Boyinsh
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    2018-08-25 zhaohui6731
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