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Diabetologia：随着时间的推移，1型糖尿病缓慢进展者失去胰岛自身抗体并表现出明显的CD95hi B细胞表型？

2020-07-27 MedSci原创 MedSci原创

1型糖尿病；缓慢进展者
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本研究的目的是鉴定1型糖尿病缓慢进展者的胰岛自身抗体和免疫细胞表型。

本研究的目的是鉴定1型糖尿病缓慢进展者的胰岛自身抗体和免疫细胞表型。

研究人员通过从缓慢进展者、1型糖尿病患者、新诊断或长期存在的1型糖尿病患者和健康个体获得的外周血样本，比较免疫变量。研究人员利用多色流式细胞术用于分析B细胞和T细胞的表型属性。用酶联免疫斑点(ELISpot)测定胰岛自身抗原特异性B细胞，用肽- hla I类四聚体测定胰岛自身抗原特异性CD8+ T细胞。用放射免疫法检测胰岛自身抗体。通过ELISAs检测血清中各种趋化因子、细胞因子和可溶性受体。

研究结果显示，胰岛自身抗体随着时间的推移在缓慢进展者中消失。与健康供体的相应B细胞亚群相比，在慢进展者中，特别是在多克隆刺激后，各种B细胞亚群表达的CD95水平更高(p < 0.05)。缓慢进展者和健康供者CD4+和CD8+ T细胞表型特征相似。与健康供者相比，慢进展者中具有中心记忆表型的CD4+ T细胞(CD27int、CD127+、CD95int)的频率更低(CD4+ T细胞的平均百分比为3.00%，而健康供者为4.67%，p < 0.05)。与健康供者相比，缓慢进展者自身反应性B细胞对胰岛素原的反应频率更高。ELISpot实验中，健康供体的斑点数为0，慢进展者为24.34，p < 0.05。胰岛自身抗原特异性CD8+ T细胞应答在缓慢进展者和健康供体中基本不存在。与健康供体相比，慢进展者血清DcR3 (CD95L的诱变受体)水平升高(中位数为1087 pg/ml，健康供体为651 pg/ml, p = 0.06)。

在这项研究中，我们发现1型糖尿病的缓慢进展与胰岛自身抗体的缺失和独特的B细胞表型有关，这与CD95介导的外周自身反应性增强的凋亡调节相一致。这些表型变化需要在更大的群体中进行进一步的研究，以确定其功能含义。

原始出处：

Stephanie J. Hanna, Wendy E. Powell,Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype

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    2021-07-13 仁医06

    #DIA#

    0

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    2020-12-03 ms5439512287675881

    #BET#

    0

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    2020-11-12 habb

    #CD95#

    0

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    2020-09-06 baoya

    #胰岛#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1639544, encodeId=1b3a16395445f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Jul 13 15:33:57 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761464, encodeId=8f541e6146479, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Dec 03 13:33:57 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782762, encodeId=50c41e82762f2, content=<a href='/topic/show?id=761343e74e' target=_blank style='color:#2F92EE;'>#CD95#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4377, encryptionId=761343e74e, topicName=CD95)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Thu Nov 12 11:33:57 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750163, encodeId=73ca1e501631c, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Sep 06 05:33:57 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273364, encodeId=432812e3364ca, content=<a href='/topic/show?id=310d383ef5' target=_blank style='color:#2F92EE;'>#B细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3837, encryptionId=310d383ef5, topicName=B细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Wed Jul 29 13:33:57 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535274, encodeId=141b15352e4a8, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Wed Jul 29 13:33:57 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043248, encodeId=adb5104324818, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 28 01:33:57 CST 2020, time=2020-07-28, status=1, ipAttribution=)]
    2020-07-29 xiaoyeshuang

    #B细胞#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1639544, encodeId=1b3a16395445f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Jul 13 15:33:57 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761464, encodeId=8f541e6146479, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Dec 03 13:33:57 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782762, encodeId=50c41e82762f2, content=<a href='/topic/show?id=761343e74e' target=_blank style='color:#2F92EE;'>#CD95#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4377, encryptionId=761343e74e, topicName=CD95)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Thu Nov 12 11:33:57 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750163, encodeId=73ca1e501631c, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Sep 06 05:33:57 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273364, encodeId=432812e3364ca, content=<a href='/topic/show?id=310d383ef5' target=_blank style='color:#2F92EE;'>#B细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3837, encryptionId=310d383ef5, topicName=B细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Wed Jul 29 13:33:57 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535274, encodeId=141b15352e4a8, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Wed Jul 29 13:33:57 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043248, encodeId=adb5104324818, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 28 01:33:57 CST 2020, time=2020-07-28, status=1, ipAttribution=)]
    2020-07-29 tastas

    #表型#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1639544, encodeId=1b3a16395445f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Jul 13 15:33:57 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761464, encodeId=8f541e6146479, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Dec 03 13:33:57 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782762, encodeId=50c41e82762f2, content=<a href='/topic/show?id=761343e74e' target=_blank style='color:#2F92EE;'>#CD95#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4377, encryptionId=761343e74e, topicName=CD95)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Thu Nov 12 11:33:57 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750163, encodeId=73ca1e501631c, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Sep 06 05:33:57 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273364, encodeId=432812e3364ca, content=<a href='/topic/show?id=310d383ef5' target=_blank style='color:#2F92EE;'>#B细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3837, encryptionId=310d383ef5, topicName=B细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Wed Jul 29 13:33:57 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535274, encodeId=141b15352e4a8, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Wed Jul 29 13:33:57 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043248, encodeId=adb5104324818, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 28 01:33:57 CST 2020, time=2020-07-28, status=1, ipAttribution=)]
    2020-07-28 misszhang

    谢谢MedSci提供最新的资讯

    0