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Am J Clin Nutr：摄入镁/钾盐可改善卒中后功能结局

2017-12-26 徐晓涵 环球医学

镁/钾盐改善卒中后功能结局
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卒中是死亡和神经功能缺陷的主要原因之一。急需改善神经功能结局的管理措施。既往在老年人中进行的干预试验已经成功使用了盐作为钾的载体，证实富含钾的食盐可降低心血管死亡率41%。饮食中的镁与人类较低的糖尿病和/或卒中相关，在动物中具有神经保护作用。2017年《Am J Clin Nutr》的一项研究调查了富含镁的盐是否会为卒中康复提供额外获益。

卒中是死亡和神经功能缺陷的主要原因之一。急需改善神经功能结局的管理措施。既往在老年人中进行的干预试验已经成功使用了盐作为钾的载体，证实富含钾的食盐可降低心血管死亡率41%。饮食中的镁与人类较低的糖尿病和/或卒中相关，在动物中具有神经保护作用。2017年《Am J Clin Nutr》的一项研究调查了富含镁的盐是否会为卒中康复提供额外获益。

目的：鉴于相当大比例的台湾人轻微缺乏钾和镁，盐作为矿物质的一种良好载体，进一步研究富含镁（以接近膳食参考摄入量（DRI）的量）的盐是否会为卒中康复提供额外获益。

设计：这是一项双盲随机对照试验，由291名卒中出院患者（改良Rankin量表（mRS）≤4）组成。研究分为3组：常规的盐（Na盐）（99人）、富含钾的盐（K盐）（97人）、富含钾和镁的盐（K/Mg盐）（95人）。于出院、3个月、6个月时评估NIH卒中量表（NIHSS）、Barthel指数（BI）和mRS。良好的神经功能表现的定义为NIHSS=0，BI=100，mRS≤1。

结果：6个月的干预后，良好神经功能表现的患者比例增加幅度在K/Mg盐组中比在K盐和Na盐组中大。K/Mg盐组实现良好神经功能表现的OR比Na盐组显着性增加（2.25；95% CI，1.09~4.67）。但是K盐的效果不具显着性差异（OR：1.58；95% CI，0.77~3.22）。

结论：在食盐中提供DRI推荐量的镁和钾，有益于卒中患者从神经功能缺陷中康复。

原始出处：

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    2018-05-16 waiwai3039

    #卒中后#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1671324, encodeId=c41f16e132402, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Wed May 16 00:20:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301069, encodeId=f497130106923, content=<a href='/topic/show?id=10333293491' target=_blank style='color:#2F92EE;'>#功能结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32934, encryptionId=10333293491, topicName=功能结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d275294, createdName=andy2087, createdTime=Thu Dec 28 11:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273152, encodeId=e88a2e31528a, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu Dec 28 08:23:11 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272884, encodeId=10ab2e288467, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 27 09:38:56 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-28 andy2087

    #功能结局#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1671324, encodeId=c41f16e132402, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Wed May 16 00:20:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301069, encodeId=f497130106923, content=<a href='/topic/show?id=10333293491' target=_blank style='color:#2F92EE;'>#功能结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32934, encryptionId=10333293491, topicName=功能结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d275294, createdName=andy2087, createdTime=Thu Dec 28 11:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273152, encodeId=e88a2e31528a, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu Dec 28 08:23:11 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272884, encodeId=10ab2e288467, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 27 09:38:56 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-28 半夏微凉

    学习了.谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1671324, encodeId=c41f16e132402, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Wed May 16 00:20:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301069, encodeId=f497130106923, content=<a href='/topic/show?id=10333293491' target=_blank style='color:#2F92EE;'>#功能结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32934, encryptionId=10333293491, topicName=功能结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d275294, createdName=andy2087, createdTime=Thu Dec 28 11:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273152, encodeId=e88a2e31528a, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu Dec 28 08:23:11 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272884, encodeId=10ab2e288467, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 27 09:38:56 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-27 186****0580(小山羊）

    学习了谢谢了

    0