J Gastroenterology:Barrett食管与结肠癌之间的关系

2019-09-18 不详 MedSci原创

鉴于Barrett食管(BE)疾病有癌变的可能,因此对于BE进行适当管理和监测是非常有必要的。结直肠肿瘤(CRNs)的存在是BE发生和食管腺癌(EAC)发生的危险因素。因此,本项研究旨在评估了BE或EAC与结肠疾病(包括肿瘤和憩室病)之间的关系。

背景
鉴于Barrett食管(BE)疾病有癌变的可能,因此对于BE进行适当管理和监测是非常有必要的。结直肠肿瘤(CRNs)的存在是BE发生和食管腺癌(EAC)发生的危险因素。因此,本项研究旨在评估了BE或EAC与结肠疾病(包括肿瘤和憩室病)之间的关系。

方法
研究人员?收集了2016年1月至2017年12月期间在三个机构接受结肠镜检查和食管十二指肠镜检查的患者(N = 5606)的临床数据。并对结肠疾病和BE或EAC的存在的关系进行了回顾性研究。

结果
BE≥1cm或≥3cm的患病率分别为13.0%和0.52%。BE与结直肠腺瘤的存在密切相关(48.4% VS  37.2%; P<0.001),腺癌(16.6% VS 8.4%,P<0.001)和结肠憩室病(CD)(34.1% vs 29.3%,P<0.001)。在长节段BE患者中,CRNs(79.3%,P<0.001)和CD(48.2%,P= 0.038)更常见。与非BE患者相比,EAC患者的CRN发生率也有统计学意义(87.5% VS 45.6%,P= 0.027)。远端结肠憩室病与EAC和BE显着相关(50.0%,P= 0.010和15.4%,P= 0.024),反流性食管炎(t= 5.26,P<0.001)和食管裂孔疝(t= 11.68,P<0.001)是BE的预测因子。

结论
CRN的存在与BE和EAC密切相关。因此,结肠镜检查可能有助于帮助BE的监测与管理

原始出处:

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    2020-03-31 ysjykql
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    2020-04-27 许安
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    2019-09-20 zhouqu_8
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    2019-09-20 yangeasy

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