JCO:多喝咖啡,结肠癌3期病人死亡率和肿瘤复发率降低!

2015-08-19 陈说 译 MedSci原创

来自达纳法伯癌症研究所研究人员一项新的研究表明,若结肠癌3期的患者经常喝含咖啡因的咖啡,则可显著降低机体肿瘤复发的几率,并提高患者生存率。且咖啡摄入量为4杯/天或更多则对患者的身体功能越好。这项研究发表在临床肿瘤学杂志上。达纳胃肠肿瘤研究中心主任Charles Fuchs说道:“我们发现,饮用咖啡的人患癌风险低,且若患癌症则治愈几率更大”。美国人平均每天要喝三杯咖啡,54%的美国人每天喝18杯咖啡

来自达纳法伯癌症研究所研究人员一项新的研究表明,若结肠癌3期的患者经常喝含咖啡因的咖啡,则可显著降低机体肿瘤复发的几率,并提高患者生存率。且咖啡摄入量为4杯/天或更多则对患者的身体功能越好。这项研究发表在临床肿瘤学杂志上。


达纳胃肠肿瘤研究中心主任Charles Fuchs说道:“我们发现,饮用咖啡的人患癌风险低,且若患癌症则治愈几率更大”。

美国人平均每天要喝三杯咖啡,54%的美国人每天喝18杯咖啡。在如此庞大的数字面前,研究人员重点关注咖啡等热饮料也不足为奇。

饮用咖啡会为机体带来一系列问题。既往研究表明,咖啡摄入过多会增加认知障碍的风险,但会降低男性勃起障碍的风险;对女性而言,研究人员发现,对于患有乳腺癌且服用他莫昔芬的患者若饮用咖啡至少2杯/天,则复发几率减半。

在胰岛素水平高于正常的人群中,结肠癌更容易复发,同时饮用咖啡量多也会减少患2型糖尿病的风险并增加机体胰岛素的敏感性。然而,咖啡摄入量对结肠癌患者的的生存率和复发率的影响尚无人知晓。

研究人员进行了一项前瞻性研究,他们对953例3期结肠癌患者在接受化疗后6个月内进行了一项膳食问卷调查。关注的主要目标是咖啡、不含中草药成分的茶饮、和咖啡因对患者肿瘤复发率和死亡率的影响。

他们发现,在随访期间,每天喝四杯或更多(咖啡因含量至少为460mg)的患者,比不喝咖啡的患者肿瘤复发的几率要低42%、死亡率低33%。更进一步的研究分析表明,降低癌症患者肿瘤复发率和死亡率的是咖啡中的咖啡因,而不是咖啡中的其他成分。

但是对于确切机制,研究人员尚不清楚,但研究人员认为,咖啡因的摄入可能会增加胰岛素敏感性。这意味着身体分泌胰岛素会稍减少,这样有可能减少机体的炎症反应(导致机体出现癌症或糖尿病的高危因素)。鉴于研究尚未完成,作用的确切机制尚不明确,因此研究人员尚未公开宣布最佳的日常咖啡摄入量。

Fuchs教授说道:“如果你是位结肠癌患者,同时你又很喜欢喝咖啡,那么你可以继续喝咖啡;但是如果你之前没有喝过咖啡,那么你就不要贸然地和咖啡,至少要跟你的主管医生商量沟通一下。”

原始出处:

Charles S. Fuchs et al.Coffee intake, recurrence, and mortality in stage III colon cancer: results from CALGB 89803 (Alliance),Journal of Clinical Oncology.17 August 2015

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1922399, encodeId=5a5f192239999, content=<a href='/topic/show?id=4a80425e534' target=_blank style='color:#2F92EE;'>#复发率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42575, encryptionId=4a80425e534, topicName=复发率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sat May 14 03:03:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705581, encodeId=e7d51e0558129, content=<a href='/topic/show?id=0f5a8288537' target=_blank style='color:#2F92EE;'>#肿瘤复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82885, encryptionId=0f5a8288537, topicName=肿瘤复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a4e30995147, createdName=AspirantSuo, createdTime=Sun Jun 12 10:03:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891210, encodeId=557a18912101a, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Jun 13 17:03:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36024, encodeId=093536024d9, content=如果没有结肠癌,喝咖啡可以预防吗?这是个重要的议题, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16671645175, createdName=1ddb46eem97(暂无匿称), createdTime=Mon Aug 24 11:20:00 CST 2015, time=2015-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35872, encodeId=bc3b358e258, content=这个有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Thu Aug 20 02:34:00 CST 2015, time=2015-08-20, status=1, ipAttribution=)]
    2016-06-13 lidong40
  4. [GetPortalCommentsPageByObjectIdResponse(id=1922399, encodeId=5a5f192239999, content=<a href='/topic/show?id=4a80425e534' target=_blank style='color:#2F92EE;'>#复发率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42575, encryptionId=4a80425e534, topicName=复发率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sat May 14 03:03:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705581, encodeId=e7d51e0558129, content=<a href='/topic/show?id=0f5a8288537' target=_blank style='color:#2F92EE;'>#肿瘤复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82885, encryptionId=0f5a8288537, topicName=肿瘤复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a4e30995147, createdName=AspirantSuo, createdTime=Sun Jun 12 10:03:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891210, encodeId=557a18912101a, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Jun 13 17:03:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36024, encodeId=093536024d9, content=如果没有结肠癌,喝咖啡可以预防吗?这是个重要的议题, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16671645175, createdName=1ddb46eem97(暂无匿称), createdTime=Mon Aug 24 11:20:00 CST 2015, time=2015-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35872, encodeId=bc3b358e258, content=这个有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Thu Aug 20 02:34:00 CST 2015, time=2015-08-20, status=1, ipAttribution=)]
    2015-08-24 1ddb46eem97(暂无匿称)

    如果没有结肠癌,喝咖啡可以预防吗?这是个重要的议题

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1922399, encodeId=5a5f192239999, content=<a href='/topic/show?id=4a80425e534' target=_blank style='color:#2F92EE;'>#复发率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42575, encryptionId=4a80425e534, topicName=复发率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sat May 14 03:03:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705581, encodeId=e7d51e0558129, content=<a href='/topic/show?id=0f5a8288537' target=_blank style='color:#2F92EE;'>#肿瘤复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82885, encryptionId=0f5a8288537, topicName=肿瘤复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a4e30995147, createdName=AspirantSuo, createdTime=Sun Jun 12 10:03:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891210, encodeId=557a18912101a, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Jun 13 17:03:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36024, encodeId=093536024d9, content=如果没有结肠癌,喝咖啡可以预防吗?这是个重要的议题, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16671645175, createdName=1ddb46eem97(暂无匿称), createdTime=Mon Aug 24 11:20:00 CST 2015, time=2015-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35872, encodeId=bc3b358e258, content=这个有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Thu Aug 20 02:34:00 CST 2015, time=2015-08-20, status=1, ipAttribution=)]
    2015-08-20 byzh1990

    这个有意思

    0

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