Hypertension:脉搏波速度可预测慢性肾病的进展

2018-05-29 国际循环编辑部 国际循环

慢性肾病(CKD)患者即使血压控制良好,仍有极高的长期肾衰竭和死亡风险。近期,发表于Hypertension的一篇文章对动脉硬化是否会影响CKD的进展和死亡风险进行阐述。

慢性肾病(CKD)患者即使血压控制良好,仍有极高的长期肾衰竭和死亡风险。近期,发表于Hypertension的一篇文章对动脉硬化是否会影响CKD的进展和死亡风险进行阐述。

研究人员开展一项名为慢性肾功能不全(CRIC)的前瞻性队列研究,探讨患者的颈-股动脉脉搏波速度(PWV)与出现终末期肾病(ESRD)事件、ESRD或肾小球滤过率减半事件或各种原因所致死亡之间的相关性。研究共入组2795例患者,平均年龄60周岁,其中56.4%为男性,47.3%为糖尿病患者,基线平均肾小球滤过率为44.4 mL·min·1.73 m2。研究结果显示,随访期共出现504例ESRD事件、628例ESRD或肾小球滤过率减半事件以及394例死亡。PWV处于最高的三分位数(>10.3 m/s)中的患者,他们的ESRD风险(HR=1.37,95%CI:1.05~1.80)、ESRD或肾小球滤过率减半风险(HR=1.25,95%CI:0.98~1.58)以及死亡风险(HR=1.72,95%CI:1.24~2.38)都相对更高。

研究人员认为,可将PWV作为肾功能不全患者CKD进展和死亡的重要预测手段,这将有利于CKD患者改善预后。但是,减轻主动脉硬化程度是否有助于降低CKD患者的死亡风险仍需研究证据支持。

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    2018-07-25 feather89
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    2018-05-30 wzb521zf

    一起学习学习

    0

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    2018-05-29 happsf

    学习

    0

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    2018-05-29 1e0f8808m18(暂无匿称)

    学习了.谢谢分享!

    0