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Brit J Cancer：月经初潮年龄和绝经年龄与结直肠癌的风险！

2018-05-25 xing.T MedSci原创

月经初潮年龄绝经年龄结直肠癌风险
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由此可见，该研究并不支持月经初潮年龄和绝经年龄的遗传风险评分与CRC风险之间的因果关系。

大量证据支持绝经后使用激素治疗与降低结直肠癌（CRC）风险之间的相关性，这表明外源性激素在CRC发生发展中的作用。然而，内源性雌激素暴露与CRC之间的结果仍不一致。

近日，肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章，研究人员使用孟德尔随机化方法检测了月经初潮年龄和绝经年龄作为内源性雌激素暴露的指标对CRC风险的因果效应。基于358个与月经初潮年龄相关的单核苷酸多态性和51个与绝经年龄相关的单核苷酸多态性加权遗传风险评分被用来估计CRC的风险，通过对来自于三个样本的12944里诊断为CRC和10741例无CRC的女性进行Logistic回归分析。研究人员进行了敏感性分析，以解决多效性和可能的混淆因素，如体重指数。

月经初潮年龄（每年比值比为0.98，95%可信区间为0.95-1.02）和绝经年龄（每年比值比为0.98，95%可信区间为0.94-1.01）的遗传风险评分与CRC风险并无显著相关性。敏感性分析得到了类似的结果。

由此可见，该研究并不支持月经初潮年龄和绝经年龄的遗传风险评分与CRC风险之间的因果关系。

原始出处：

Sonja Neumeyer, et al. Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. British Journal of Cancer. 2018. https://www.nature.com/articles/s41416-018-0108-8

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    2018-08-16 ms7019579240139182

    #绝经年龄#

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    2019-03-11 pyaili

    #月经初潮#

    0

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    2019-02-18 zhucaizhong7775

    #初潮#

    0

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createdName=三生有幸9135, createdTime=Fri May 25 15:26:37 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318471, encodeId=49cc3184e17e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri May 25 13:41:14 CST 2018, time=2018-05-25, status=1, ipAttribution=)]
    2018-05-27 cscdliu

    学习了.谢谢

    0

  5. 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    2018-05-27 yeye5224612

    #绝经#

    0

  6. 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    2018-05-27 luwei00

    #月经#

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=318769, encodeId=93b6318e6966, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat May 26 16:00:23 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318494, encodeId=556c318494fb, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri May 25 15:26:37 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318471, encodeId=49cc3184e17e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri May 25 13:41:14 CST 2018, time=2018-05-25, status=1, ipAttribution=)]
    2018-05-27 crystal0564

    #结直肠#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2055024, encodeId=ba3420550242d, content=<a href='/topic/show?id=dd47e8901d9' target=_blank style='color:#2F92EE;'>#绝经年龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78901, encryptionId=dd47e8901d9, topicName=绝经年龄)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Thu Aug 16 07:31:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019044, encodeId=06322019044dd, content=<a href='/topic/show?id=620f6055844' target=_blank style='color:#2F92EE;'>#月经初潮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60558, encryptionId=620f6055844, topicName=月经初潮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b3e473, createdName=pyaili, createdTime=Mon Mar 11 03:31:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677690, encodeId=de8616e769029, content=<a href='/topic/show?id=53fb32222ca' target=_blank style='color:#2F92EE;'>#初潮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32222, encryptionId=53fb32222ca, topicName=初潮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74f427571521, createdName=zhucaizhong7775, createdTime=Mon Feb 18 11:31:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319097, encodeId=2cd431909ecd, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Sun May 27 15:49:32 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257163, encodeId=61e0125e1632d, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun May 27 04:31:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376802, encodeId=7a2d13e68027f, content=<a href='/topic/show?id=f8216055671' target=_blank style='color:#2F92EE;'>#月经#</a>, 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GetPortalCommentsPageByObjectIdResponse(id=318769, encodeId=93b6318e6966, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat May 26 16:00:23 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318494, encodeId=556c318494fb, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri May 25 15:26:37 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318471, encodeId=49cc3184e17e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri May 25 13:41:14 CST 2018, time=2018-05-25, status=1, ipAttribution=)]
    2018-05-26 Jackie Li

    学习

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=318769, encodeId=93b6318e6966, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat May 26 16:00:23 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318494, encodeId=556c318494fb, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri May 25 15:26:37 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318471, encodeId=49cc3184e17e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri May 25 13:41:14 CST 2018, time=2018-05-25, status=1, ipAttribution=)]
    2018-05-25 三生有幸9135

    学习一下谢谢分享

    0

  10. 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createdName=三生有幸9135, createdTime=Fri May 25 15:26:37 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318471, encodeId=49cc3184e17e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri May 25 13:41:14 CST 2018, time=2018-05-25, status=1, ipAttribution=)]
    2018-05-25 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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