台研究团队发现致癌主导基因

2018-05-03 贾钊、陈键兴 新华社

台湾“中研院”生物医学研究所2日发布最新研究成果,称发现癌细胞中过度表现的致癌基因paraspeckle Component 1(PSPC1)会促使癌细胞增生、侵袭、转移。未来若能抑制这一基因的表现,便能减低癌细胞生长、扩散,有助于研发新治癌药物。据悉,相关研究论文已于日前发表在《自然细胞生物学》杂志上。记者从“中研院”当日召开的记者会上了解到,癌症病患死亡主因之一是癌化肿瘤细胞的侵袭和转移,而此

台湾“中研院”生物医学研究所2日发布最新研究成果,称发现癌细胞中过度表现的致癌基因paraspeckle Component 1(PSPC1)会促使癌细胞增生、侵袭、转移。未来若能抑制这一基因的表现,便能减低癌细胞生长、扩散,有助于研发新治癌药物。据悉,相关研究论文已于日前发表在《自然细胞生物学》杂志上。

记者从“中研院”当日召开的记者会上了解到,癌症病患死亡主因之一是癌化肿瘤细胞的侵袭和转移,而此前研究已发现,转化生长因子-β1(TGF-β1)的信息传递在癌转移的机制上扮演重要角色。但由于该因子既能抑制正常细胞增生,也会促进癌细胞增生、侵袭和转移,科学界并不清楚其在癌症不同阶段发挥的作用。

为找出细胞癌化的关键因子,该机构的相关研究团队利用全基因体分析肺癌、乳癌、肝癌、前列腺癌等恶性肿瘤,寻找肿瘤组织中有基因套数变异、表现异常与病患存活率相关的基因。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1797653, encodeId=cf181e976531c, content=<a href='/topic/show?id=2975232445e' target=_blank style='color:#2F92EE;'>#主导基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23244, encryptionId=2975232445e, topicName=主导基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Sep 05 02:54:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370942, encodeId=1d6213e0942d2, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat May 05 00:54:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570050, encodeId=860b15e005003, content=<a href='/topic/show?id=f60de338081' target=_blank style='color:#2F92EE;'>#研究团队#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73380, encryptionId=f60de338081, topicName=研究团队)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15c315623764, createdName=changhe718, createdTime=Sat May 05 00:54:00 CST 2018, time=2018-05-05, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1797653, encodeId=cf181e976531c, content=<a href='/topic/show?id=2975232445e' target=_blank style='color:#2F92EE;'>#主导基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23244, encryptionId=2975232445e, topicName=主导基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Sep 05 02:54:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370942, encodeId=1d6213e0942d2, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat May 05 00:54:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570050, encodeId=860b15e005003, content=<a href='/topic/show?id=f60de338081' target=_blank style='color:#2F92EE;'>#研究团队#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73380, encryptionId=f60de338081, topicName=研究团队)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15c315623764, createdName=changhe718, createdTime=Sat May 05 00:54:00 CST 2018, time=2018-05-05, status=1, ipAttribution=)]
    2018-05-05 jambiya
  3. [GetPortalCommentsPageByObjectIdResponse(id=1797653, encodeId=cf181e976531c, content=<a href='/topic/show?id=2975232445e' target=_blank style='color:#2F92EE;'>#主导基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23244, encryptionId=2975232445e, topicName=主导基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Sep 05 02:54:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370942, encodeId=1d6213e0942d2, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat May 05 00:54:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570050, encodeId=860b15e005003, content=<a href='/topic/show?id=f60de338081' target=_blank style='color:#2F92EE;'>#研究团队#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73380, encryptionId=f60de338081, topicName=研究团队)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15c315623764, createdName=changhe718, createdTime=Sat May 05 00:54:00 CST 2018, time=2018-05-05, status=1, ipAttribution=)]