Circ Cardiovasc Imaging:心房颤动患者的瓣膜叶面重塑不足会出现啥结果?

2017-03-20 xing.T MedSci原创

在房颤患者中,瓣膜叶面重塑跟不上瓣环扩张,而不是单纯的瓣环扩张,与MR的严重程度密切相关。

房颤动(AF)和二尖瓣返流(MR)引起的瓣环扩张之间的关系仍存在争议。最近,血管领域权威杂志Circulation-Cardiovascular Imaging上发表了一篇研究文章。研究人员假设小的瓣膜总叶面积/环面积比(TLA/AA),反映瓣膜叶面重塑跟不上瓣环扩张,从而导致房颤患者发生MR,并且是其主要原因。

研究人员对28例中度或重度MR患者(MR组)、年龄和性别匹配的56例轻度以下MR的房颤患者(非MR组)和16例对照者进行三维超声心动图检查并对二尖瓣的数据进行分析。

研究人员发现在MR组(645±126平方毫米/平方米,P<0.001)和非MR组(568±121平方毫米/平方米,P=0.001)患者中显著增大,相比于对照组参与者(444±108平方毫米/平方米)。然而,在MR组患者中TLA/AA明显减小(1.29±0.10,P<0.001),但在非MR组(1.65±0.24,P>0.99)并未减小,与对照者相比(1.70±0.29)。在线性回归分析中,TLA/AA与有效返流孔大小成负相关(r=-0.73,P<0.001)。TLA/AA接受者操作特征曲线下面积显著高于AA(0.95 vs. 0.72,P<0.001)。多变量分析显示较小的TLA/AA(P<0.001)和显著MR独立相关,而与AA无关(P=0.26)。

在房颤患者中,瓣膜叶面重塑跟不上瓣环扩张,而不是单纯的瓣环扩张,与MR的严重程度密切相关。

原始出处:

Nobuyuki Kagiyama,et al. Insufficient Leaflet Remodeling in Patients With Atrial Fibrillation Association With the Severity of Mitral Regurgitation. Circ Cardiovasc Imaging. 2017. https://doi.org/10.1161/CIRCIMAGING.116.005451

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    2018-03-01 quxin068
  2. [GetPortalCommentsPageByObjectIdResponse(id=1938656, encodeId=852a193865606, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Mar 01 05:24:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182403, encodeId=ce8e182403a8, content=学习新知识谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 24 12:51:34 CST 2017, time=2017-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583499, encodeId=970b1583499a8, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Wed Mar 22 08:24:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626833, encodeId=575716268338c, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Wed Mar 22 08:24:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181462, encodeId=48ed18146263, content=在房颤患者中,瓣膜叶面重塑跟不上瓣环扩张,而不是单纯的瓣环扩张,与MR的严重程度密切相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Mon Mar 20 17:50:16 CST 2017, time=2017-03-20, status=1, ipAttribution=)]
    2017-03-24 虈亣靌

    学习新知识谢谢分享

    0

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    2017-03-22 sodoo
  5. [GetPortalCommentsPageByObjectIdResponse(id=1938656, encodeId=852a193865606, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Mar 01 05:24:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182403, encodeId=ce8e182403a8, content=学习新知识谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 24 12:51:34 CST 2017, time=2017-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583499, encodeId=970b1583499a8, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Wed Mar 22 08:24:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626833, encodeId=575716268338c, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Wed Mar 22 08:24:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181462, encodeId=48ed18146263, content=在房颤患者中,瓣膜叶面重塑跟不上瓣环扩张,而不是单纯的瓣环扩张,与MR的严重程度密切相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Mon Mar 20 17:50:16 CST 2017, time=2017-03-20, status=1, ipAttribution=)]
    2017-03-20 Albert Wu

    在房颤患者中,瓣膜叶面重塑跟不上瓣环扩张,而不是单纯的瓣环扩张,与MR的严重程度密切相关。

    0

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