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ACS Appl Mater Interfaces：IFN-γ和TNF-α联合应用可有效诱导Hela细胞的凋亡

2018-03-17 MedSci MedSci原创

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使用外部方法诱导癌细胞死亡是癌症治疗的主要策略之一。研究表明TNF-α常用于肿瘤生物治疗，而IFN-γ可直接抑制肿瘤细胞增殖。在我们的研究中，将TNF-α和IFN-γ共固定在聚苯乙烯材料（PSt）或Fe3O4-油酸纳米颗粒（NPs）上。然后可以观察到这两种蛋白质的结构变化。同时，基因芯片分析确定TNF-α和IFN-α的表达显著增加，然而，在存在TNF-α和IFN-α抑制剂的情况下，共同移植的IFN

使用外部方法诱导癌细胞死亡是癌症治疗的主要策略之一。研究表明TNF-α常用于肿瘤生物治疗，而IFN-γ可直接抑制肿瘤细胞增殖。

在我们的研究中，将TNF-α和IFN-γ共固定在聚苯乙烯材料（PSt）或Fe3O4-油酸纳米颗粒（NPs）上。然后可以观察到这两种蛋白质的结构变化。同时，基因芯片分析确定TNF-α和IFN-α的表达显著增加，然而，在存在TNF-α和IFN-α抑制剂的情况下，共同移植的IFN-γ和TNF-α诱导的HeLa细胞中TNF-α和IFN-α的表达并没有增加。

我们的研究结果表明，这种改变可以刺激HeLa细胞分泌更多的TNF-α和IFN-α，从而进一步诱导HeLa细胞的凋亡。本研究是自分泌诱导HeLa细胞凋亡的首次报道。此外，我们还进行了ELISA、RT-PCR、流式细胞术和Western blot分析，以及一系列动物水平的分析测试。

我们的数据还表明，PSt共修饰的IFN-γ和TNF-α对于体内癌症治疗具有明显的效果，对于转化成临床治疗具有重要意义。

原始出处：

Li J, Zhang Y, et al., Cervical Cancer HeLa Cell Autocrine Apoptosis Induced by Coimmobilized IFN-γ plus TNF-α Biomaterials. ACS Appl Mater Interfaces. 2018 Mar 14;10(10):8451-8464. doi: 10.1021/acsami.7b18277. Epub 2018 Mar 2.

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    2018-09-28 shanyongle

    #ACE#

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    2018-07-21 s_pl2017

    #联合应用#

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    2019-02-23 夏天与十三菇凉

    #FAC#

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    2018-03-19 yaanren

    #ACS#

    0

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    2018-03-19 snowpeakxu

    #TNF#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1655844, encodeId=fac616558445d, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Fri Sep 28 06:38:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684172, encodeId=ab4e16841e246, content=<a href='/topic/show?id=7425806967a' target=_blank style='color:#2F92EE;'>#联合应用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80696, encryptionId=7425806967a, topicName=联合应用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091d28056243, createdName=s_pl2017, createdTime=Sat Jul 21 18:38:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956681, encodeId=6b3619566819b, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Sat Feb 23 17:38:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279243, encodeId=aa5d12e92432f, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Mon Mar 19 02:38:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401671, encodeId=79c714016e1c0, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Mon Mar 19 02:38:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519031, encodeId=b928151903146, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Mon Mar 19 02:38:00 CST 2018, time=2018-03-19, status=1, ipAttribution=)]
    2018-03-19 bugit

    #IFN#

    0