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Clinica Chimica Acta：lncRNA可作2型糖尿病患者为诊断标志物？

2020-02-06 MedSci MedSci原创

2型糖尿病患者
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为了筛选与葡萄糖激酶调节蛋白基因(GCKR)相关的长链非编码RNA (lncRNA)，我们分析了在2型糖尿病(T2DM)患者和对照组中的差异表达。并验证lncRNA与GCKR的相关性，评估其作为T2DM分子标志物的潜在价值。

为了筛选与葡萄糖激酶调节蛋白基因(GCKR)相关的长链非编码RNA (lncRNA)，我们分析了在2型糖尿病(T2DM)患者和对照组中的差异表达。并验证lncRNA与GCKR的相关性，评估其作为T2DM分子标志物的潜在价值。

研究人员提取5例T2DM患者和5例非T2DM患者的淋巴细胞RNA，并通过芯片获得循环lncRNA和mRNA的表达谱。同时，选取127例T2DM患者和130例非T2DM患者，通过生物信息学分析筛选与GCKR基因相关的lncRNA。通过real-time PCR检测两组患者GCKR基因和lncRNA (ENST00000588707.1和TCONS_00004187)的表达水平，并进行相关分析。通过受试者工作特征曲线分析，循环ENST00000588707.1和TCONS_00004187作为诊断T2DM的生物标记物的值。

我们从表达谱中鉴定出68个lncRNA和74个mRNA差异表达。 与对照组相比，T2DM组GCKR基因，lncRNA ENST00000588707.1和TCONS_00004187的表达水平明显降低（P <0.05）。 相关分析表明，ENST00000588707.1和TCONS_00004187与GCKR基因表达和糖脂代谢相关（P <0.05）。 ROC分析显示，T2DM患者和非T2DM患者之间的ENST00000588707.1曲线下面积为0.816（95％CI：0.764-0.869，敏感性72.0％，特异性80.3％），TCONS_00004187的AUC值为0.826（ 95％CI：0.774-0.879，敏感性81.6％，特异性61.3％）。

研究结果显示，lncRNA ENST0000588707.1和TCONS_00004187可作为T2DM的潜在生物标志物，通过调控GCKR基因参与糖脂代谢。

原始出处：

Qi Ma，Li Wang，Association between lncRNA and GCKR gene in type 2 diabetes mellitus

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    2020-05-07 windight

    #CTA#

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    2020-08-25 yanjie6253_56072842

    #CRN#

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    2020-08-25 仁心济世

    #诊断标志#

    0

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    2021-01-10 hukaixun

    #标志物#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1849843, encodeId=31f0184984361, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Thu May 07 21:29:00 CST 2020, time=2020-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005719, encodeId=aa972005e19fb, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Tue Aug 25 05:29:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812994, encodeId=52541812994e8, content=<a href='/topic/show?id=2f37916269b' target=_blank style='color:#2F92EE;'>#诊断标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91626, encryptionId=2f37916269b, topicName=诊断标志)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Aug 25 00:29:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841474, encodeId=7ab718414e4f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Jan 10 01:29:00 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990217, encodeId=23a4199021e52, content=<a href='/topic/show?id=5c719162ef1' target=_blank style='color:#2F92EE;'>#诊断标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91627, encryptionId=5c719162ef1, topicName=诊断标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d17305, createdName=listen318, createdTime=Thu Mar 19 02:29:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301918, encodeId=b6cc130191870, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Sat Feb 08 14:29:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383608, encodeId=1a1713836088f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sat Feb 08 14:29:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474883, encodeId=0bc414e488387, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Feb 08 14:29:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042963, encodeId=0f111042963ff, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Feb 07 02:29:00 CST 2020, time=2020-02-07, status=1, ipAttribution=)]
    2020-03-19 listen318

    #诊断标志物#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1849843, encodeId=31f0184984361, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Thu May 07 21:29:00 CST 2020, time=2020-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005719, encodeId=aa972005e19fb, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Tue Aug 25 05:29:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812994, encodeId=52541812994e8, content=<a href='/topic/show?id=2f37916269b' target=_blank style='color:#2F92EE;'>#诊断标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91626, encryptionId=2f37916269b, topicName=诊断标志)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Aug 25 00:29:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841474, encodeId=7ab718414e4f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Jan 10 01:29:00 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990217, encodeId=23a4199021e52, content=<a href='/topic/show?id=5c719162ef1' target=_blank style='color:#2F92EE;'>#诊断标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91627, encryptionId=5c719162ef1, topicName=诊断标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d17305, createdName=listen318, createdTime=Thu Mar 19 02:29:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301918, encodeId=b6cc130191870, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Sat Feb 08 14:29:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383608, encodeId=1a1713836088f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sat Feb 08 14:29:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474883, encodeId=0bc414e488387, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Feb 08 14:29:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042963, encodeId=0f111042963ff, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Feb 07 02:29:00 CST 2020, time=2020-02-07, status=1, ipAttribution=)]
    2020-02-08 xzw113

    #lncRNA#

    0

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    2020-02-08 aids213

    #2型糖尿病患者#

    0

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    2020-02-08 xue8604

    #糖尿病患者#

    0

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    2020-02-07 misszhang

    谢谢MedSci提供最新的资讯

    0

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