Front Cell Infect Microbiol:金黄色葡萄球菌感染研究进展

2017-04-24 MedSci MedSci原创

耐甲氧西林金黄色葡萄球菌(MRSA),是临床上最常见的医院来院的分离菌株之一,近年来在社区中出现的频率也逐渐增加。在中国,SCCmecIII-ST239菌株在不同的地理区域均有传播,约占研究的总的MRSA的75%。该研究者对来自2012年2月到2013年3月期间,从苏州的三甲医院收集的150例非复制的MRSA菌株进行了特征性描述,探讨分子流行病学。所有的菌株均使用spa分型,SCCmec分型、MR

耐甲氧西林金黄色葡萄球菌(MRSA),是临床上最常见的医院来院的分离菌株之一,近年来在社区中出现的频率也逐渐增加。在中国,SCCmecIII-ST239菌株在不同的地理区域均有传播,约占研究的总的MRSA的75%。

该研究者对来自2012年2月到2013年3月期间,从苏州的三甲医院收集的150例非复制的MRSA菌株进行了特征性描述,探讨分子流行病学。所有的菌株均使用spa分型,SCCmec分型、MRSA杀白细胞毒素(PVL)的基因编码和中毒性休克毒素(TSST-1)来进行特征描述。代表性的基因型也进行了多位点序列分型(MLST)。采用BD Phoenix自动微生物学系统进行药敏试验。分子分型包含了11种克隆亚型以及28种spa分型。其中最常见的是CC5-spat002 (29.3%) 和CC239-spat037 (14.7%)亚型。SCCmec的Ⅱ、Ⅲ、Ⅳ、Ⅴ亚型分别占总的菌株的33.3%、 21.3%、23.3%及21.3%。PVL基因在所有菌株中检测出有11.3%,TSST-1基因占总的菌株的18%,主要在CC5中检出。

有18名患者在入院后30天内死亡,院内30天死亡率为12%。多变量数据分析表明,大于60岁(odds ratio [OR] = 7.2,P= 0.026)、癌症(OR = 9.6,P= 0.022)、MRSA分离菌株tst-1(OR = 62.5,P< 0.001)均是院内30天死亡的风险因素。

研究发现,tst1阳性的CC5菌株具有较高是致死风险,因此,为了防止这些菌株的进一步传播,更为严格的预防感染措施有待加强。

原始出处:

Wang M, Zheng Y, Mediavilla JR,et al.Hospital Dissemination of tst-1-Positive Clonal Complex 5 (CC5) Methicillin-Resistant Staphylococcus aureus.Front Cell Infect Microbiol. 2017 Mar 31;7:101. doi: 10.3389/fcimb.2017.00101. eCollection 2017.

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    2017-11-13 xjy02
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    2017-07-26 sunylz
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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Apr 26 03:39:00 CST 2017, time=2017-04-26, status=1, ipAttribution=)]
    2017-07-14 维他命
  5. 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Apr 26 03:39:00 CST 2017, time=2017-04-26, status=1, ipAttribution=)]
  6. 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  7. 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    2017-05-04 cuiyejia

    学习了,谢谢

    0

  8. 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    2017-05-03 绛珠草小姐

    学习了,谢谢分享

    0

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