Clin Gastroenterol H:在肝移植候选者中,非酒精性脂肪性肝炎是肝细胞癌病因中增长快速的

2018-07-13 董洪静,高沿航(吉林大学第一医院 ) 临床肝胆病杂志

乙肝和丙肝是肝细胞癌(HCC)的主要病因,但最近非酒精性脂肪性肝炎(NASH)成为了肝癌的重要病因。本研究的目的是评估美国肝移植(LT)候选人中肝细胞癌的病因。

乙肝和丙肝是肝细胞癌(HCC)的主要病因,但最近非酒精性脂肪性肝炎(NASH)成为了肝癌的重要病因。本研究的目的是评估美国肝移植(LT)候选人中肝细胞癌的病因。

用移植受者的科学登记表(2002年-2016年) 来估计在肝移植候选人中肝细胞癌的流行趋势,最常见类型的慢性肝病:酒精性肝病(ALD)、慢性乙型肝炎(CHB)、慢性丙型肝炎和非酒精性脂肪性肝炎。

158347名成人肝移植候选人被包括在内。其中,26121例(16.5%)肝细胞癌;这一比例从2002年的6.4%上升到 2016年的23.0%。在研究期间,慢性丙型肝炎仍然是肝细胞癌最常见的病因(65%)。 慢性丙型肝炎和酒精性肝病所占比例保持稳定的趋势,慢性乙肝的比例下降了3.1倍,而非酒精性脂肪性肝炎的比例增加了7.7倍(从2.1%提高到16.2%)。

此外,自2002年以来,在等候肝移植的肝细胞癌患者中,非酒精性脂肪性肝炎增加了11.8倍,慢性乙型肝炎增加6.0倍,酒精性肝病增加了3.4倍,慢性丙型肝炎增加了2.3倍;非酒精性脂肪性肝炎的增长趋势较其他病因更明显。最终进行移植或在等待过程中死亡的肝细胞癌移植候选人的病因之间没有差异。

在美国肝移植候选者中,非酒精性脂肪性肝病是肝细胞癌病因中增长最快的病因。

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objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Sep 25 02:36:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956043, encodeId=4e1e1956043e1, content=<a href='/topic/show?id=8a048435058' target=_blank style='color:#2F92EE;'>#脂肪性肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84350, encryptionId=8a048435058, topicName=脂肪性肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Jr8S1dfvNyP22t32IFDXJXnpd5AGlDibiajL5cl3pxj7OPCeAeibLhzOmZn5Q2Oicc6uKOCnxGNOggdLtI3hIW7huQ/132, createdBy=66e52500008, createdName=Tamikia, createdTime=Wed Mar 13 05:36:00 CST 2019, time=2019-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863377, encodeId=846818633e7d8, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Dec 11 06:36:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978717, encodeId=c8a219e8717ba, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sat Feb 23 18:36:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332113, encodeId=f08e3321137a, content=谢谢了.学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Tue Jul 17 01:02:44 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-12-20 qjddjq
  5. [GetPortalCommentsPageByObjectIdResponse(id=1711564, encodeId=abce1e11564b2, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu May 30 23:36:00 CST 2019, time=2019-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673414, encodeId=f3b516e3414ce, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1711564, encodeId=abce1e11564b2, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu May 30 23:36:00 CST 2019, time=2019-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673414, encodeId=f3b516e3414ce, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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time=2019-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863377, encodeId=846818633e7d8, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Dec 11 06:36:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978717, encodeId=c8a219e8717ba, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sat Feb 23 18:36:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332113, encodeId=f08e3321137a, content=谢谢了.学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Tue Jul 17 01:02:44 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-09-25 许安
  7. 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  8. 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createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sat Feb 23 18:36:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332113, encodeId=f08e3321137a, content=谢谢了.学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Tue Jul 17 01:02:44 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-12-11 xjy02
  9. 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createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sat Feb 23 18:36:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332113, encodeId=f08e3321137a, content=谢谢了.学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Tue Jul 17 01:02:44 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-17 txqjm

    谢谢了.学习

    0

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本研究旨在评估基于肝细胞癌(HCC)桥接肝移植患者的免疫标记物和肿瘤生物学对于经导管动脉化学栓塞(TACE)反应,并为移植后复发风险制定出优化的移植前模型,并将结果发表在Radiology上。

Transplantation:利妥昔单抗单药且无额外脱敏治疗用于ABO血型不合活体供肝肝移植的可行性分析

近年来,在肝移植领域,随着各种防治抗体介导的排斥反应(AMR)策略的临床运用,如利妥昔单抗等免疫抑制剂、血浆置换(PP)、移植物局部灌注(LI)与脾切除等,使得ABO血型不合肝移植(ABO-i LT)成功案例的报道逐渐增多。

Nature:使用“生命支持系统”在体温下保存肝脏或可改善移植结果

根据本周《自然》在线发表的一篇论文A randomized trial of normothermic preservation in liver transplantation,体温保存肝或有助于改善移植结果,增加可用供肝数量,从而降低等待肝移植者的死亡率。

Lancet Gastroenterology& Hepatology:进行新辅助化疗病情稳定的肝内胆管癌患者再进行肝移植或可改善预后

目前,肝内胆管癌是肝移植的禁忌症。但既往该领域的研究并不能根据新辅助化疗后对化疗的敏感性或病程轨迹进行预选患者。肝门胆管癌的经验提示,新辅助化疗后进行肝移植,对于无病程进展的患者可获得长期的存活效益。现Keri E Lunsford等人尝试在有生物学反应的肝内胆管癌患者(即肿瘤稳定或经新辅助化疗后病情恢复) 中评估肝移植的潜在疗效。在本前瞻性病例系列中,患者要求是局部晚期未进行手术切除的肝内胆管癌

Hepatology:重构肝细胞癌患者的治疗方法:采用HALTHCC进行纵向 评估,改善了切除和等待策略

HALTHCC在评估等待进行肝移植的肝癌患者的肿瘤风险方面是优势的,随着时间的推移,它的效用也在增加。在对肝细胞凋亡、死亡及复发危险的区分中,HALTHCC的相对变化优于mRECIST。