BMJ：饮酒少者心血管系统更健康

酒精脱氢酶1B基因（ADH1B）的多态性rs1229984 认为与饮酒有关，也认为这是酒精与心血管疾病关系的分子基础。但是以往研究考虑较少。

最新一项基于孟尔随随机的meta分析，荟萃了56个流行病学研究数据，合计261991个欧洲人群，其中20259例患者合并冠脉疾病，10164位患者伴有卒中事件。

结果发现，与非携带者相比，A-allele of ADH1B rs1229984携带者每周少消费17.2%单位酒精（95%CI：15.6% to 18.9%），同样binge饲料也使用较少（OR：0.78 (95% CI 0.73 to 0.84)），但有更高的禁饮者（OR：1.27 (1.21 to 1.34)）。同时，Rs1229984 A-allele携带者有更低的收缩压(-0.88 (-1.19 to -0.56) mm Hg)，IL-6水平(-5.2% (-7.8 to -2.4%))，更低腰围(-0.3 (-0.6 to -0.1) cm)和BMI (-0.17 (-0.24 to -0.10)kg/m(2) 。Rs1229984 A-allele携带者有更低的冠脉疾病（OR=0.90 (0.84 to 0.96)）。但是，rs1229984 多态性与卒中并不相关，但是其亚型A等位基因有更低的缺血性卒中发生（OR=0.83 (0.72 to 0.95)）。

最终研究显示，少饮酒或酒精消费量低的人群，更有利于心血管的健康。

（同篇阅读：BMJ：饮酒是“伤心”还是“护心”？）

Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, Cavadino A, Drogan D, Padmanabhan S, Li S, Yesupriya A, Leusink M, Sundstrom J, Hubacek JA, Pikhart H, Swerdlow DI, Panayiotou AG, Borinskaya SA, Finan C, Shah S, Kuchenbaecker KB, Shah T, Engmann J, Folkersen L, Eriksson P, Ricceri F, Melander O, Sacerdote C, Gamble DM, Rayaprolu S, Ross OA, McLachlan S, Vikhireva O, Sluijs I, Scott RA, Adamkova V, Flicker L, Bockxmeer FM, Power C, Marques-Vidal P, Meade T, Marmot MG, Ferro JM, Paulos-Pinheiro S, Humphries SE, Talmud PJ, Mateo Leach I, Verweij N, Linneberg A, Skaaby T, Doevendans PA, Cramer MJ, Harst Pv, Klungel OH, Dowling NF, Dominiczak AF, Kumari M, Nicolaides AN, Weikert C, Boeing H, Ebrahim S, Gaunt TR, Price JF, Lannfelt L, Peasey A, Kubinova R, Pajak A, Malyutina S, Voevoda MI, Tamosiunas A, Maitland-van der Zee AH, Norman PE, Hankey GJ, Bergmann MM, Hofman A, Franco OH, Cooper J, Palmen J, Spiering W, Jong PA, Kuh D, Hardy R, Uitterlinden AG, Ikram MA, Ford I, Hyppönen E, Almeida OP, Wareham NJ, Khaw KT, Hamsten A, Husemoen LL, Tjønneland A, Tolstrup JS, Rimm E, Beulens JW, Verschuren WM, Onland-Moret NC, Hofker MH, Wannamethee SG, Whincup PH, Morris R, Vicente AM, Watkins H, Farrall M, Jukema JW, Meschia J, Cupples LA, Sharp SJ, Fornage M, Kooperberg C, LaCroix AZ, Dai JY, Lanktree MB, Siscovick DS, Jorgenson E, Spring B, Coresh J, Li YR, Buxbaum SG, Schreiner PJ, Ellison RC, Tsai MY, Patel SR, Redline S, Johnson AD, Hoogeveen RC, Hakonarson H, Rotter JI, Boerwinkle E, Bakker PI, Kivimaki M, Asselbergs FW, Sattar N, Lawlor DA, Whittaker J, Davey Smith G, Mukamal K, Psaty BM, Wilson JG, Lange LA, Hamidovic A, Hingorani AD, Nordestgaard BG, Bobak M, Leon DA, Langenberg C, Palmer TM, Reiner AP, Keating BJ, Dudbridge F, Casas JP; InterAct Consortium.Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ. 2014 Jul 10;349:g4164. doi: 10.1136/bmj.g4164