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Diabetes：Neurturin和GLP-1类似物协同作用缓解Zucker糖尿病肥胖大鼠糖尿病！

2017-04-17 xing.T MedSci原创

NeurturinGLP-1糖尿病
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这些结果表明针对不同机制的联合治疗可以减轻晚期糖尿病。这强调对于控制不佳的糖尿病患者联合治疗可以更有效地管理糖尿病。

Neurturin（NRTN），是胶质细胞来源的神经营养因子（GDNF）家族中的一员，是从鸡胚胎胰腺cDNA文库中筛选分泌因子过程中找到的。近日，糖尿病领域权威杂志Diabetes上发表了一篇研究文章，研究人员在Zucker糖尿病肥胖大鼠（ZDF）上评估了NRTN的潜在抗糖尿病活性，相比于利拉鲁肽，一种GLP-1受体激动剂。

研究人员在8周大小的雄性ZDF大鼠皮下注射NRTN预防高血糖的发生，并且改善代谢参数，其效果与利拉鲁肽相类似。研究人员发现NRTN治疗可以增加胰腺胰岛素含量和β细胞的质量，防止胰岛组织恶化。然而，与接受利拉鲁肽治疗的大鼠不一样的是，NRTN介导的改善并不与降低体重或食物摄入量相关。

急性NRTN治疗没有激活ZDF大鼠脑中主要控制摄食和代谢中心中c-Fos的表达，或直接增强葡萄糖刺激胰腺β细胞的胰岛素分泌。持续高血糖的10周龄ZDF大鼠给予利拉鲁肽治疗导致高血糖有所缓解，而NRTN是没有效果的，尽管其可以改善血脂和空腹血糖水平。有趣的是，联合使用NRTN和利拉鲁肽可以使高血糖以及其他代谢指标回归正常。

这些结果表明针对不同机制的联合治疗可以减轻晚期糖尿病。这强调对于控制不佳的糖尿病患者联合治疗可以更有效地管理糖尿病。

原始出处：

James L. Trevaskis, et al. Neurturin and a Glp-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.Diabetes 2017. http://diabetes.diabetesjournals.org/content/early/2017/04/13/db16-0916

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    2017-05-12 木头人513

    #Diabetes#

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    2018-02-13 ms9608593228839890

    #DIA#

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    2017-08-19 ms5439512287675881

    #BET#

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    2017-04-19 yibei

    #GLP-1#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1901610, encodeId=92f2190161063, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri May 12 19:23:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637692, encodeId=7e5a163e69295, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Feb 13 07:23:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759935, encodeId=7ee51e5993561, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Aug 19 07:23:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422703, encodeId=591f1422e031c, content=<a href='/topic/show?id=54fa80e701' target=_blank style='color:#2F92EE;'>#GLP-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8077, encryptionId=54fa80e701, topicName=GLP-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f23732777, createdName=yibei, createdTime=Wed Apr 19 04:23:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188394, encodeId=4f5a1883949f, content= 学习了，受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/17/c120bd9d36e25c0e9366af82eb2a01bc.jpg, createdBy=41011660769, createdName=lily01208, createdTime=Tue Apr 18 07:25:52 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188300, encodeId=374618830087, content=知识很前沿，学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f772050400, createdName=1391ebac8dm, createdTime=Mon Apr 17 20:59:56 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188253, encodeId=b3c51882536d, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Mon Apr 17 15:32:23 CST 2017, time=2017-04-17, status=1, ipAttribution=)]
    2017-04-18 lily01208

    学习了，受益

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1901610, encodeId=92f2190161063, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri May 12 19:23:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637692, encodeId=7e5a163e69295, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Feb 13 07:23:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759935, encodeId=7ee51e5993561, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Aug 19 07:23:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422703, encodeId=591f1422e031c, content=<a href='/topic/show?id=54fa80e701' target=_blank style='color:#2F92EE;'>#GLP-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8077, encryptionId=54fa80e701, topicName=GLP-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f23732777, createdName=yibei, createdTime=Wed Apr 19 04:23:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188394, encodeId=4f5a1883949f, content= 学习了，受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/17/c120bd9d36e25c0e9366af82eb2a01bc.jpg, createdBy=41011660769, createdName=lily01208, createdTime=Tue Apr 18 07:25:52 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188300, encodeId=374618830087, content=知识很前沿，学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f772050400, createdName=1391ebac8dm, createdTime=Mon Apr 17 20:59:56 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188253, encodeId=b3c51882536d, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Mon Apr 17 15:32:23 CST 2017, time=2017-04-17, status=1, ipAttribution=)]
    2017-04-17 1391ebac8dm

    知识很前沿，学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1901610, encodeId=92f2190161063, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri May 12 19:23:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637692, encodeId=7e5a163e69295, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Feb 13 07:23:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759935, encodeId=7ee51e5993561, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Aug 19 07:23:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422703, encodeId=591f1422e031c, content=<a href='/topic/show?id=54fa80e701' target=_blank style='color:#2F92EE;'>#GLP-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8077, encryptionId=54fa80e701, topicName=GLP-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f23732777, createdName=yibei, createdTime=Wed Apr 19 04:23:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188394, encodeId=4f5a1883949f, content= 学习了，受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/17/c120bd9d36e25c0e9366af82eb2a01bc.jpg, createdBy=41011660769, createdName=lily01208, createdTime=Tue Apr 18 07:25:52 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188300, encodeId=374618830087, content=知识很前沿，学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f772050400, createdName=1391ebac8dm, createdTime=Mon Apr 17 20:59:56 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188253, encodeId=b3c51882536d, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Mon Apr 17 15:32:23 CST 2017, time=2017-04-17, status=1, ipAttribution=)]
    2017-04-17 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0