INFECT DIS P:巴西成人戊型肝炎的血清流行率如何?

2019-01-31 MedSci MedSci原创

戊型肝炎病毒(HEV)是肝病毒科的一种;包括四种主要的基因型及一种血清型。1型和2型基因可引起流行性肝炎,通过水和粪口途径传播,而3型和4型基因是人畜共患型。在巴西的各种戊型肝炎血清流行率研究中,报告差异很大,且难以解释。本研究旨在分析巴西成人戊型肝炎的血清流行率现况。 研究人员通过检索PubMed、拉丁美洲和加勒比卫生科学和Embase数据库,包括截止到 2018年5月12日在巴西发表的无

戊型肝炎病毒(HEV)是肝病毒科的一种;包括四种主要的基因型及一种血清型。1型和2型基因可引起流行性肝炎,通过水和粪口途径传播,而3型和4型基因是人畜共患型。在巴西的各种戊型肝炎血清流行率研究中,报告差异很大,且难以解释。本研究旨在分析巴西成人戊型肝炎的血清流行率现况。

研究人员通过检索PubMed、拉丁美洲和加勒比卫生科学和Embase数据库,包括截止到 2018512日在巴西发表的无时间和语言限制的HEV感染研究。纳入研究的条件为:含有关于巴西成年人数据,样本量≥50岁且经标准化和商业化戊型肝炎抗体检测的病人。此外,还使用一个总共包含9个项目标准列表来评估文章的质量。在最终分析的20项研究中,包含巴西东南部10(50%),中西部3项(15%),北部3项(15%),东北部2项(10%),南部2项(10%)。对于质量评价的研究,平均分数为5.6(范围:4−8)HEV感染的成年人的估计总体血清流行率为6.0%95%置信区间CI:5.0−7.0);在亚组分析中,研究人员发现抗HEV抗体在献血者的患病率为7.0%95%置信区间CI:5.0−8.0),而在一般人群中为3.0%95% CI:2.0−4.0)。

研究结果表明,巴西应在预防戊型肝炎病毒感染方面进行国家投入,包括改善基本卫生和关于适当处理动物粪便和最佳烹调蔬菜、肉类及其衍生物方面的指导。

原始出处:

Fátima Mitiko Tengan, Gerusa M. Figueiredo, Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis

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    2019-10-24 lixiaol
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    2019-01-31 lietome15

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

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