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J Periodontol：BMP-2/7促进牙槽骨再生的非手术基因转移疗法

2017-08-25 MedSci MedSci原创

BMP-2/7牙槽骨再生非手术基因疗法
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牙槽骨是保证牙齿固位极其重要的组织；然而，一旦牙槽骨缺失，它可能无法自然再生。目前，临床通常应用骨移植物或人造骨来实施牙槽骨再生疗法。然而，此类疗法需要开展外科手术治疗，存在一定的风险，特别是对年长患者而言。因此，研发非手术性的牙槽骨再生技术就显得十分必要。众所周知，骨膜和牙周膜中存在干细胞，它可以诱导分化为成骨细胞。在这篇研究中，作者推测：通过电穿孔的方法在体内移植骨形成蛋白(BMP)-2/7至

牙槽骨是保证牙齿固位极其重要的组织；然而，一旦牙槽骨缺失，它可能无法自然再生。目前，临床通常应用骨移植物或人造骨来实施牙槽骨再生疗法。然而，此类疗法需要开展外科手术治疗，存在一定的风险，特别是对年长患者而言。因此，研发非手术性的牙槽骨再生技术就显得十分必要。众所周知，骨膜和牙周膜中存在干细胞，它可以诱导分化为成骨细胞。在这篇研究中，作者推测：通过电穿孔的方法在体内移植骨形成蛋白(BMP)-2/7至牙周组织中，以此可以诱导外源性的BMP产物，进而诱导牙周组织中的干细胞分化为成骨细胞，促进新生牙槽骨的产生。研究将BMP-2/7基因的表达载体通过电穿孔的方法导入大鼠上颌第一磨牙牙周组织的目标位置。结果显示，在牙周组织的目标区域检测到BMP-2/7的表达，并且在基因转移后5天发现有新生的牙槽骨组织增长。在第7天，新生的牙槽骨组织与最初的骨组织相连接。并且，在BMP2/7基因转移后，牙槽骨的矿物质沉积率要比lacZ基因转移做对照的牙槽骨明显增高。结论：这篇研究表明，非病毒性的BMP2/7载体结合电穿孔方法预示着牙槽骨再生疗法又出现了一种有效的非手术选择。原始出处：Kawai M， Kataoka

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    2018-03-21 mei540

    #牙槽骨#

    0

  2. 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    2018-04-12 HNYYM

    #BMP#

    0

  3. 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content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2018-02-23 feather89

    #PE#

    0

  4. 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content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-28 12498f1em08(暂无昵称)

    #牙槽骨再生#

    0

  5. 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content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-12-27 12498f17m73暂无昵称

    #BMP-2#

    0

  6. 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content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-28 戒馋，懒，贪

    谢谢分享

    0

  7. 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encodeId=bd5f23e6136f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sun Aug 27 08:18:22 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237295, encodeId=35a923e295a7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 26 08:03:37 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237279, encodeId=cf8c23e27976, content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-27 lsj630

    #骨再生#

    0

  8. 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encodeId=bd5f23e6136f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sun Aug 27 08:18:22 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237295, encodeId=35a923e295a7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 26 08:03:37 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237279, encodeId=cf8c23e27976, content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-27 往日如昨

    学习了谢谢分享

    0

  9. 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encodeId=bd5f23e6136f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sun Aug 27 08:18:22 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237295, encodeId=35a923e295a7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 26 08:03:37 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237279, encodeId=cf8c23e27976, content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 清风拂面

    谢谢分享.学习了

    0

  10. 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encodeId=bd5f23e6136f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sun Aug 27 08:18:22 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237295, encodeId=35a923e295a7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 26 08:03:37 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237279, encodeId=cf8c23e27976, content=非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Aug 26 07:42:02 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 天涯183

    非常好的文章.学习了.很受益

    0

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