Brit J Cancer:芬兰人前列腺癌随机筛选研究中空腹血糖、血糖控制与前列腺癌风险关系研究

2018-03-25 AlexYang MedSci原创

糖尿病男性具有更低的前列腺癌(PCa)总风险,但是高血糖征在其中的角色情况不清楚。在研究中,研究人员评估了具有糖尿病空腹血糖水平男性的PCa风险。研究人员将参与者与实验室数据相联系,目的是为了追溯自从1978年的血糖测量信息,可利用的数据涉及到17860名男性。根据年平均水平,这些男性被归类为正常血糖水平、糖尿病前期和糖尿病。平均跟踪调查的时间为14.7年。研究人员还利用调整后的多变量Cox回归计

糖尿病男性具有更低的前列腺癌(PCa)总风险,但是高血糖征在其中的角色情况不清楚。在研究中,研究人员评估了具有糖尿病空腹血糖水平男性的PCa风险。研究人员将参与者与实验室数据相联系,目的是为了追溯自从1978年的血糖测量信息,可利用的数据涉及到17860名男性。根据年平均水平,这些男性被归类为正常血糖水平、糖尿病前期和糖尿病。平均跟踪调查的时间为14.7年。研究人员还利用调整后的多变量Cox回归计算了前列腺癌中生存的风险比(HRs)和95%置信区间(95%CIs),并利用格林森等级和转阶段进行区分。

研究发现,总共诊断了1663个PCa个案例。与正常血糖男性比较,那些具有糖尿病血糖水平的男性PCa风险增加(HR 1.52; 95% CI 1.31-1.75)。另外,在所有肿瘤等级中均观察到了风险增加,并且之后持续10年左右。抗糖尿病药物的使用能够消除上述风险相关性。研究的局限性在于生活方式因素的信息和BMI有限的信息。最后,研究人员指出,未治疗的空腹糖尿病血糖水平也许是前列腺癌的风险因子。

原始出处:

Teemu J. Murtola, Ville JY Vihervuori, Jorma Lahtela et al. Fasting blood glucose, glycaemic control and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer. Brit J Cancer. 22 Mar 2018.

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    2018-09-11 sjq027
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    2018-04-06 梦想起航ing

    很好的视频.不错.学习了.谢谢分享!!

    0

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