Prostate Int:刺龙菊木提取物对亚硝基甲基脲(NMU)诱导的前列腺癌具有保护性作用

2017-06-22 AlexYang MedSci原创

最近,有研究人员评估了刺龙菊木提取物对小鼠中亚硝基甲基脲(NMU)诱导的前列腺癌和DU-145细胞系可能保护作用。研究人员通过提供环丙氯地孕酮、睾酮和亚硝基甲基脲在30只雄性霍尔茨曼小鼠中诱导前列腺癌的形成。研究人员对肿瘤进行了检测,并记录了血液学和生化参数以及嗜多染红细胞微核数目。并通过细胞毒性试验对细胞系进行评估。研究发现,对小鼠进行刺龙菊木提取物口服给药可以显著的降低超氧化物歧化酶丙二醛、N

最近,有研究人员评估了刺龙菊木提取物对小鼠中亚硝基甲基脲(NMU)诱导的前列腺癌和DU-145细胞系可能保护作用。研究人员通过提供环丙氯地孕酮、睾酮和亚硝基甲基脲在30只雄性霍尔茨曼小鼠中诱导前列腺癌的形成。研究人员对肿瘤进行了检测,并记录了血液学和生化参数以及嗜多染红细胞微核数目。并通过细胞毒性试验对细胞系进行评估。

研究发现,对小鼠进行刺龙菊木提取物口服给药可以显著的降低超氧化物歧化酶丙二醛、NO、C反应蛋白和前列腺特异抗原水平(和电感组比较均为P<0.01)。另外,嗜多染红细胞微核的频率显著的降低(P<0.05)。刺龙菊木提取物在细胞毒性试验中展现了17.24的选择性指数。

最后,研究人员指出,考虑到刺龙菊木提取物的抗炎、抗氧化和抗遗传毒性效果,以及重要的生化和血液学参数的改变,包括了前泪先特异抗原参数改变,他们认为在小鼠中,刺龙菊木提取物对亚硝基甲基脲(NMU)诱导的前列腺癌和DU-145细胞系的毒性具有保护性作用。

原始出处:

Arroyo-Acevedo J, Herrera-Calderón O, Chávez-Asmat R et al. Protective effect of Chuquir aga spinosa extract on N-methyl-nitrosourea (NMU) induced prostate cancer in rats. Prostate Int. Jun 2017.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=216768, encodeId=ddae216e6887, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 29 18:54:39 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215324, encodeId=d0d321532487, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 25 18:28:06 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364193, encodeId=45cb13641935f, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sat Jun 24 12:02:00 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601877, encodeId=da0f16018e78a, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sat Jun 24 12:02:00 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214311, encodeId=c2a9214311b1, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Jun 23 09:29:17 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214199, encodeId=1e082141993c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri Jun 23 07:34:21 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-29 虈亣靌

    不错的,学习了,谢谢分享!

    0

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    2017-06-25 虈亣靌

    不错的,学习了,谢谢分享!

    0

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    2017-06-24 lsndxfj
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    2017-06-24 sunylz
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    2017-06-23 Y—xianghai

    学习了新知识

    0

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