J Glaucoma:睡眠呼吸暂停综合征会让眼睛也伤痕累累

2016-05-18 Seven L 译 MedSci原创

近期一项研究结果表明,睡眠呼吸暂停综合症会增加患者视网膜神经纤维层厚度变薄的风险。珠海中山大学的研究人员对2011年至2014年涉及1,034只眼睛的6项研究进行了荟萃分析,所有的研究评估了以下一个或多个指标:平均视网膜神经纤维层(RNFL)厚度;四象限(上、鼻、下、颞)RNFL厚度;不同阻塞性睡眠呼吸暂停综合征(OSAS)阶段RNFL厚度。研究排除了一下患者:怀疑或确证青光眼、视神经炎、慢性葡萄

近期一项研究结果表明,睡眠呼吸暂停综合征会增加患者视网膜神经纤维层厚度变薄的风险。

珠海中山大学的研究人员对2011年至2014年涉及1,034只眼睛的6项研究进行了荟萃分析,所有的研究评估了以下一个或多个指标:平均视网膜神经纤维层(RNFL)厚度;四象限(上、鼻、下、颞)RNFL厚度;不同阻塞性睡眠呼吸暂停综合征(OSAS)阶段RNFL厚度。

研究排除了一下患者:怀疑或确证青光眼、视神经炎、慢性葡萄膜炎、视网膜色素变性、眼外伤、眼部手术史、多发性硬化症、帕金森氏症或卒中

研究结果显示,轻度OSAS组RNFL厚度平均差异为 –2.05 µm,没有异质性;中度OSAS组RNFL厚度平均差异为–2.49 µm没有异质性;重度OSAS组RNFL厚度平均差异为 –6.36 µm,具有显著的异质性(P < .003)。

四象限(上、鼻、下、颞)RNFL厚度情况如下,上象限RNFL厚度组合平均差异为–1.83 µm,无异质性;鼻象限为–2.32 µm,无异质性;下象限为–3.31 µm,无异质性;颞象限为–0.75 µm,无异质性。

研究人员写道:“我们有理由相信,OSAS可以通过降低氧气供应导致青光眼、眼压增加、加重视野缺陷和减少视网膜神经纤维层厚度。不过建立OSAS和RNFL厚度之间潜在的因果关系还需要进一步的大规模、长期的前瞻性研究。”

原始出处:

Zhao XJ, et al. Obstructive Sleep Apnea and Retinal Nerve Fiber Layer Thickness: A Meta-analysis.J Glaucoma. 2016;doi:10.1097/IJG.0000000000000349.

Obstructive sleep apnea associated with decreased retinal nerve fiber layer thickness.Healio.May 17, 2016


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  2. [GetPortalCommentsPageByObjectIdResponse(id=1989008, encodeId=13671989008f8, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Feb 18 04:46:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914181, encodeId=7aee1914181ef, content=<a href='/topic/show?id=5ee629957f' target=_blank style='color:#2F92EE;'>#AUC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2995, encryptionId=5ee629957f, topicName=AUC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Tue Sep 20 23:46:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130335, encodeId=5a36130335fd, content=不错哦继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 18 15:38:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126745, encodeId=6aab126e4550, content=文章不错,值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 14 14:51:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430619, encodeId=ef96143061902, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri May 20 10:46:00 CST 2016, time=2016-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596461, encodeId=4e6815964614e, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Fri May 20 10:46:00 CST 2016, time=2016-05-20, status=1, ipAttribution=)]
    2016-09-20 aliceclz
  3. [GetPortalCommentsPageByObjectIdResponse(id=1989008, encodeId=13671989008f8, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Feb 18 04:46:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914181, encodeId=7aee1914181ef, content=<a href='/topic/show?id=5ee629957f' target=_blank style='color:#2F92EE;'>#AUC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2995, encryptionId=5ee629957f, topicName=AUC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Tue Sep 20 23:46:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130335, encodeId=5a36130335fd, content=不错哦继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 18 15:38:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126745, encodeId=6aab126e4550, content=文章不错,值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 14 14:51:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430619, encodeId=ef96143061902, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri May 20 10:46:00 CST 2016, time=2016-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596461, encodeId=4e6815964614e, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Fri May 20 10:46:00 CST 2016, time=2016-05-20, status=1, ipAttribution=)]
    2016-09-18 1e10c84am36(暂无匿称)

    不错哦继续关注

    0

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    2016-09-14 1e10c84am36(暂无匿称)

    文章不错,值得拜读

    0

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