Hum reprod update:驱动动力蛋白在卵母细胞减数分裂过程中的作用。

2017-06-27 qinqiyun MedSci原创

马达家族在人类中有14个亚类共45个驱动蛋白。大量的此类蛋白,或者其同源蛋白,在有丝分裂和减数分裂的细胞周期中都发挥重要功能。驱动蛋白在染色体分离、微管动力、纺锤体形成、细胞分离和细胞周期过程中都发挥重要作用。

马达家族在人类中有14个亚类共45个驱动蛋白。大量的此类蛋白,或者其同源蛋白,在有丝分裂和减数分裂的细胞周期中都发挥重要功能。驱动蛋白在染色体分离、微管动力、纺锤体形成、细胞分离和细胞周期过程中都发挥重要作用。本篇文章囊括一篇关于动力蛋白在女性减数分裂过程中的作用的相关研究的综述。Nicole J.Camlin及其同事探讨每种驱动蛋白在卵母细胞减数分裂过程中功能,并强调了此类蛋白家族对人类减数分裂质量的潜在的临床重要意义。

检测驱动动力蛋白在卵母细胞减数分裂中的作用。

搜索Pubmed数据库中1970年1月-2017年2月发表的文献中的数据,检索词包括“卵母细胞驱动蛋白”和“减数分裂驱动蛋白”。

人类细胞的45个驱动马达蛋白均被检测,仅其中的13个蛋白在女性减数分裂中发挥作用。而且,忽略在母体衰老、低温冷藏或者酗酒等行为时发生的基因转录或蛋白表达的改变,在哺乳动物的卵母细胞中仅检测到这13个蛋白中的一半。

驱动动力蛋白在很多非哺乳类物种的卵母细胞减数分裂过程中发挥独特而重要的作用。然而,因为缺乏研究,目前对于这些蛋白在哺乳类动物(尤其是人类)的减数分裂过程中的作用知之甚少。需要更多的关于驱动动力蛋白的科学研究,特别是在母体衰老、低温冷藏或者暴露在有害环境下时的情况。


原始出处:
Nicole J.Camlin,Eileen A.McLauglin,Janet E.Holt.Motoring through:the role of kinesin superfamily proteins in female meiosis.Human Reproduction Update.18 April 2017.https://doi.org/10.1093/humupd/dmx010.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1973548, encodeId=b51119e3548c8, content=<a href='/topic/show?id=cd233125266' target=_blank style='color:#2F92EE;'>#减数分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31252, encryptionId=cd233125266, topicName=减数分裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca6a2500099, createdName=more is better!, createdTime=Mon Nov 13 10:12:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796619, encodeId=ce5c1e96619aa, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jan 16 13:12:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601881, encodeId=4f9f160188194, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625552, encodeId=cc4116255525c, content=<a href='/topic/show?id=95513689242' target=_blank style='color:#2F92EE;'>#卵母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36892, encryptionId=95513689242, topicName=卵母细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3b120824706, createdName=qingting, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1973548, encodeId=b51119e3548c8, content=<a href='/topic/show?id=cd233125266' target=_blank style='color:#2F92EE;'>#减数分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31252, encryptionId=cd233125266, topicName=减数分裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca6a2500099, createdName=more is better!, createdTime=Mon Nov 13 10:12:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796619, encodeId=ce5c1e96619aa, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jan 16 13:12:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601881, encodeId=4f9f160188194, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625552, encodeId=cc4116255525c, content=<a href='/topic/show?id=95513689242' target=_blank style='color:#2F92EE;'>#卵母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36892, encryptionId=95513689242, topicName=卵母细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3b120824706, createdName=qingting, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2018-01-16 docwu2019
  3. [GetPortalCommentsPageByObjectIdResponse(id=1973548, encodeId=b51119e3548c8, content=<a href='/topic/show?id=cd233125266' target=_blank style='color:#2F92EE;'>#减数分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31252, encryptionId=cd233125266, topicName=减数分裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca6a2500099, createdName=more is better!, createdTime=Mon Nov 13 10:12:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796619, encodeId=ce5c1e96619aa, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jan 16 13:12:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601881, encodeId=4f9f160188194, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625552, encodeId=cc4116255525c, content=<a href='/topic/show?id=95513689242' target=_blank style='color:#2F92EE;'>#卵母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36892, encryptionId=95513689242, topicName=卵母细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3b120824706, createdName=qingting, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-06-29 sunylz
  4. [GetPortalCommentsPageByObjectIdResponse(id=1973548, encodeId=b51119e3548c8, content=<a href='/topic/show?id=cd233125266' target=_blank style='color:#2F92EE;'>#减数分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31252, encryptionId=cd233125266, topicName=减数分裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca6a2500099, createdName=more is better!, createdTime=Mon Nov 13 10:12:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796619, encodeId=ce5c1e96619aa, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jan 16 13:12:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601881, encodeId=4f9f160188194, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625552, encodeId=cc4116255525c, content=<a href='/topic/show?id=95513689242' target=_blank style='color:#2F92EE;'>#卵母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36892, encryptionId=95513689242, topicName=卵母细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3b120824706, createdName=qingting, createdTime=Thu Jun 29 03:12:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]