Cell reports：磷酸化BAD-BH3类似物或可重建β胰岛细胞功能治疗糖尿病

2015-02-02 佚名生物谷

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近日来自美国哈佛医学院的研究人员在国际期刊cell reports发表了他们一项最新研究成果。他们通过研究发现了一种在基因和药理学上都与磷酸化BAD-BH3结构域具有相似性的类似物能够促进β细胞在受到应激刺激时产生自我保护效应并维持β细胞存活和正常功能。这项研究或对治疗I型糖尿病具有重要意义。

文章指出，促进β细胞存活并维持β细胞产生胰岛素应答葡萄糖刺激能够大大增加β细胞替代疗法治疗I型糖尿病的效果。研究人员发现磷酸化BAD-BH3结构域类似物能够有效促进β细胞在受到应激刺激时产生自我保护效应的能力，同时将这些发现用于改进供体胰岛细胞移植，能够促进糖尿病模型小鼠中β细胞在移植胰岛中的存活，重建胰岛素合成释放能力，并能够改善小鼠糖尿病状态。对机制进行研究发现，β细胞在这种背景下的存活不仅是因为磷酸化BAD失去了对促细胞存活蛋白BCL-2的抑制功能，同时，磷酸化BAD还能够刺激葡糖激酶的激活。

因此，研究人员通过实验证明，磷酸化BAD-BH3结构域类似物对促进β细胞存活和维持β细胞合成分泌胰岛素功能具有重要意义，或可用于重建糖尿病人功能性β细胞数量，进一步治疗糖尿病。

原始出处

Sanda Ljubicic, Klaudia Polak, Accalia Fu, Jessica Wiwczar, Benjamin Szlyk, Yigang Chang,Juan C. Alvarez-Perez, Gregory H. Bird, Loren D. Walensky, Adolfo Garcia-Oca?a, Nika N. Danial.Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes

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2015-02-20 baoya

#胰岛#

28 0
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2015-11-14 zhaozhouchifen

#Cell#

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2015-05-11 vividelife

#胰岛细胞#

0 0
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2015-05-17 ms3994565386320060

#BH3类似物#

34 0
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2015-05-27 维他命

#CEL#

24 0
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2015-04-11 x35042875

AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性

87 0
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2015-02-04 仁者大医

#细胞功能#

21 0

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Cell reports：磷酸化BAD-BH3类似物或可重建β胰岛细胞功能治疗糖尿病

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