Cell：天然杀手T细胞在启动B细胞抗病毒免疫反应中的作用

2018-01-29 药明康德学术经纬

B细胞是适应性免疫应答的重要一环，因为它们可以通过产生对抗原有高度特异性的抗体来保护机体不受外来病原体的伤害。

B细胞是适应性免疫应答的重要一环，因为它们可以通过产生对抗原有高度特异性的抗体来保护机体不受外来病原体的伤害。已有研究表明B细胞激活过程中受到滤泡辅助T细胞 (follicular helper T cells， TfH) 的调控，但是B细胞在淋巴节生发中心 (germinal center) 处的最初激活过程仍然没有得到澄清。麻省总医院Ragon研究所 (Ragon Institute of MGH) 的研究人员发现天然杀手T (natural killer T， NKT) 细胞在病毒感染后对激活B细胞免疫反应非常重要。这些NKT细胞位于淋巴节的滤泡间区，一方面它们可以很容易被淋巴结内的巨噬细胞激活，另一方面NKT细胞分泌的IL-4可以迅速传送给接触过抗原的B细胞。NKT细胞在病毒感染之后分泌的IL-4会产生一个IL-4水平高峰。这一IL-4 高峰早于TfH细胞分泌的IL-4导致的IL-4 高峰。这一早期IL-4高峰是激发B细胞对病毒感染的免疫反应的必要条件。这项研究表明，位于滤泡间区的NKT细胞在TfH细胞之前分泌的IL-4高峰是激发B细胞免疫反应的关键。

原始出处：

Mauro Gaya，et al.Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.Cell.Volume 172， Issue 3， p517–533.e20， 25 January 2018.

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2018-09-30 维他命

#CEL#

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2018-06-06 zhaozhouchifen

#Cell#

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2018-01-31 xiaoyeshuang

#B细胞#

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2018-01-31 cnxcy

#免疫反应#

29 0
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2018-01-31 yahu

#抗病毒#

26 0
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2018-01-30 戒馋，懒，贪

谢谢分享学习了

63 0
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2018-01-29 137****9095

henhao

70 0

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